Outside in: inversion of cell polarity controls epithelial lumen formation.

Developmental cell ·Vol. 31 ·No. 2 ·2014-10-27 ·Pages 140-2

Davis GE, Cleaver OB

Abstract

Establishment of cell polarity is important for epithelial lumen formation, and the molecular mechanisms directing this process are only partially understood. In this issue of Developmental Cell, Bryant et al. (2014) show that disassembly, membrane translocation, and reassembly of podocalyxin complexes controls epithelial cell polarization and lumen formation in 3D matrices.

MeSH Terms

Animals Cell Polarity/physiology Epithelial Cells/cytology,metabolism Humans Morphogenesis Organogenesis

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Davis George E

Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA. Electronic address: davisgeo@health.missouri.edu.

Cleaver Ondine B

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

References (9)

9 references, click to expand

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Article Info

Journal

Developmental cell

Abbr.

Dev Cell

ISSN

1878-1551

DOI

10.1016/j.devcel.2014.10.011

davisgeo@health.missouri.edu

Published

2014-10-27

Pages

140-2

Language

English

Region

United States

NLM ID

101120028

PMCID

PMC4373590

Subset

Grants

NIDDK NIH HHS · R01 DK079862 · United States

NHLBI NIH HHS · R01 HL113498 · United States

NHLBI NIH HHS · R01 HL126518 · United States

Corrections

CommentOn

PMID: 18946477

CommentOn

PMID: 20890297

External Links

PubMed source DOI: 10.1016/j.devcel.2014.10.011 PMC Full Text View journal details

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Outside in: inversion of cell polarity controls epithelial lumen formation.

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