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PMID: 18946477 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

From cells to organs: building polarized tissue.

Nature reviews. Molecular cell biology ·Vol. 9 ·No. 11 ·2008-11-00 ·Pages 887-901

Bryant DM, Mostov KE

Abstract

How do animal cells assemble into tissues and organs? A diverse array of tissue structures and shapes can be formed by organizing groups of cells into different polarized arrangements and by coordinating their polarity in space and time. Conserved design principles underlying this diversity are emerging from studies of model organisms and tissues. We discuss how conserved polarity complexes, signalling networks, transcription factors, membrane-trafficking pathways, mechanisms for forming lumens in tubes and other hollow structures, and transitions between different types of polarity, such as between epithelial and mesenchymal cells, are used in similar and iterative manners to build all tissues.

MeSH Terms
Animals Cell Communication Cell Polarity Cells Humans Neoplasms Organogenesis
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bryant David M
Department of Anatomy, University of California San Francisco, California 94143-2140, USA. david.bryant@ucsf.edu
Mostov Keith E
References (146)
146 references, click to expand
  1. Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis.
    Curr Biol. 2008 Apr 8;18(7):507-13 PMID: 18394894
  2. COPI vesicle transport is a common requirement for tube expansion in Drosophila.
    PLoS One. 2008;3(4):e1964 PMID: 18398480
  3. Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis.
    Dev Cell. 2008 Apr;14(4):570-81 PMID: 18410732
  4. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
    Nat Cell Biol. 2008 May;10(5):593-601 PMID: 18376396
  5. The epithelial-mesenchymal transition generates cells with properties of stem cells.
    Cell. 2008 May 16;133(4):704-15 PMID: 18485877
  6. Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture.
    Development. 2008 Jun;135(12):2055-64 PMID: 18480161
  7. Shroom induces apical constriction and is required for hingepoint formation during neural tube closure.
    Curr Biol. 2003 Dec 16;13(24):2125-37 PMID: 14680628
  8. Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control.
    J Cell Biol. 2004 Jan 19;164(2):313-23 PMID: 14734539
  9. Parsing the polarity code.
    Nat Rev Mol Cell Biol. 2004 Mar;5(3):220-31 PMID: 14991002
  10. Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine.
    Dev Cell. 2004 Jun;6(6):855-64 PMID: 15177033
  11. Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1.
    Dev Cell. 2004 Jun;6(6):865-73 PMID: 15177034
  12. ERK and MMPs sequentially regulate distinct stages of epithelial tubule development.
    Dev Cell. 2004 Jul;7(1):21-32 PMID: 15239951
  13. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors.
    Genes Dev. 2004 Aug 15;18(16):1909-25 PMID: 15314019
  14. A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal system.
    Curr Opin Cell Biol. 2004 Oct;16(5):493-9 PMID: 15363798
  15. Reversal of glandular polarity in the lymphovascular compartment of breast cancer.
    J Clin Pathol. 2004 Oct;57(10):1114-7 PMID: 15452174
  16. Laminin functions in tissue morphogenesis.
    Annu Rev Cell Dev Biol. 2004;20:255-84 PMID: 15473841
  17. A Rho GTPase signaling pathway is used reiteratively in epithelial folding and potentially selects the outcome of Rho activation.
    Curr Biol. 2004 Oct 26;14(20):1822-6 PMID: 15498489
  18. Ischemic damage and repair in the rat proximal tubule: differences among the S1, S2, and S3 segments.
    Kidney Int. 1978 Jul;14(1):31-49 PMID: 682423
  19. Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors.
    Cell. 1991 Aug 23;66(4):697-711 PMID: 1878968
  20. Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis.
    Dev Biol. 1998 Dec 1;204(1):64-79 PMID: 9851843
  21. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
    Nat Med. 2004 Nov;10(11):1251-6 PMID: 15502842
  22. A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.
    Nat Cell Biol. 2004 Dec;6(12):1173-9 PMID: 15558032
  23. Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells.
    J Cell Biol. 2005 Jan 17;168(2):303-13 PMID: 15642748
  24. Beta1-integrin orients epithelial polarity via Rac1 and laminin.
    Mol Biol Cell. 2005 Feb;16(2):433-45 PMID: 15574881
  25. Papillote and Piopio: Drosophila ZP-domain proteins required for cell adhesion to the apical extracellular matrix and microtubule organization.
    J Cell Sci. 2005 Feb 1;118(Pt 3):633-42 PMID: 15657084
  26. Regulation of vesicle trafficking in madin-darby canine kidney cells by Rab11a and Rab25.
    J Biol Chem. 2000 Sep 15;275(37):29138-46 PMID: 10869360
  27. Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins.
    Mol Biol Cell. 2000 Dec;11(12):4259-75 PMID: 11102522
  28. Mutant cadherin affects epithelial morphogenesis and invasion, but not transformation.
    J Cell Sci. 2001 Mar;114(Pt 6):1237-46 PMID: 11228167
  29. p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation.
    Nat Cell Biol. 2001 Apr;3(4):361-7 PMID: 11283609
  30. Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly.
    Nat Cell Biol. 2001 Sep;3(9):831-8 PMID: 11533663
  31. Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis.
    Curr Biol. 2001 Oct 2;11(19):1492-502 PMID: 11591316
  32. Morphogen gradient interpretation.
    Nature. 2001 Oct 25;413(6858):797-803 PMID: 11677596
  33. E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts.
    J Biol Chem. 2002 Feb 22;277(8):6708-18 PMID: 11744701
  34. Organogenesis: molecular mechanisms of tubulogenesis.
    Nat Rev Genet. 2002 Jul;3(7):513-23 PMID: 12094229
  35. Coordinating early kidney development: lessons from gene targeting.
    Nat Rev Genet. 2002 Jul;3(7):533-43 PMID: 12094231
  36. Opinion: Building epithelial architecture: insights from three-dimensional culture models.
    Nat Rev Mol Cell Biol. 2002 Jul;3(7):531-7 PMID: 12094219
  37. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.
    Cell. 2002 Oct 4;111(1):29-40 PMID: 12372298
  38. Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila.
    Development. 2003 Jan;130(1):173-84 PMID: 12441301
  39. Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane.
    Cell. 2002 Dec 13;111(6):879-91 PMID: 12526813
  40. Tube morphogenesis: making and shaping biological tubes.
    Cell. 2003 Jan 10;112(1):19-28 PMID: 12526790
  41. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis.
    J Cell Biol. 2003 Feb 3;160(3):375-85 PMID: 12551955
  42. Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures.
    Mol Biol Cell. 2003 Feb;14(2):748-63 PMID: 12589067
  43. Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.
    EMBO J. 2003 Mar 3;22(5):1125-33 PMID: 12606577
  44. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.
    Nat Cell Biol. 2003 Apr;5(4):301-8 PMID: 12629547
  45. Epithelial polarity and tubulogenesis in vitro.
    Trends Cell Biol. 2003 Apr;13(4):169-76 PMID: 12667754
  46. Adaptation of core mechanisms to generate cell polarity.
    Nature. 2003 Apr 17;422(6933):766-74 PMID: 12700771
  47. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.
    Cell. 2003 Jul 25;114(2):201-14 PMID: 12887922
  48. Role of polycystins in renal tubulogenesis.
    Trends Cell Biol. 2003 Sep;13(9):484-92 PMID: 12946628
  49. The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system.
    Development. 2003 Oct;130(20):4963-74 PMID: 12930776
  50. Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein.
    Nat Cell Biol. 2003 Oct;5(10):895-901 PMID: 12973360
  51. Branching morphogenesis of the Drosophila tracheal system.
    Annu Rev Cell Dev Biol. 2003;19:623-47 PMID: 14570584
  52. Distinct sites in E-cadherin regulate different steps in Drosophila tracheal tube fusion.
    Development. 2003 Dec;130(24):5989-99 PMID: 14597571
  53. Apicobasal polarization: epithelial form and function.
    Curr Opin Cell Biol. 2003 Dec;15(6):747-52 PMID: 14644201
  54. Thyroid epithelial morphogenesis in vitro: a role for bumetanide-sensitive Cl- secretion during follicular lumen development.
    Exp Cell Res. 1994 Aug;213(2):319-26 PMID: 8050488
  55. An alpha 2 beta 1 integrin-dependent pinocytic mechanism involving intracellular vacuole formation and coalescence regulates capillary lumen and tube formation in three-dimensional collagen matrix.
    Exp Cell Res. 1996 Apr 10;224(1):39-51 PMID: 8612690
  56. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group.
    Kidney Int. 1996 Sep;50(3):811-8 PMID: 8872955
  57. Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells.
    Carcinogenesis. 1997 Jun;18(6):1225-31 PMID: 9214606
  58. The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation.
    Cell. 1997 Dec 26;91(7):905-15 PMID: 9428514
  59. FAPP2 is involved in the transport of apical cargo in polarized MDCK cells.
    J Cell Biol. 2005 Aug 15;170(4):521-6 PMID: 16103222
  60. Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion.
    J Cell Biol. 2005 Aug 29;170(5):803-12 PMID: 16129787
  61. Modelling glandular epithelial cancers in three-dimensional cultures.
    Nat Rev Cancer. 2005 Sep;5(9):675-88 PMID: 16148884
  62. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management.
    Am J Respir Cell Mol Biol. 2005 Oct;33(4):319-27 PMID: 16172252
  63. Rho GTPases: biochemistry and biology.
    Annu Rev Cell Dev Biol. 2005;21:247-69 PMID: 16212495
  64. Tubulogenesis: an inside job.
    Curr Biol. 2006 Jan 24;16(2):R51-3 PMID: 16431358
  65. Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.
    Curr Biol. 2006 Jan 24;16(2):140-9 PMID: 16431366
  66. Liver regeneration.
    Hepatology. 2006 Feb;43(2 Suppl 1):S45-53 PMID: 16447274
  67. Tight junctions: molecular architecture and function.
    Int Rev Cytol. 2006;248:261-98 PMID: 16487793
  68. Complex networks orchestrate epithelial-mesenchymal transitions.
    Nat Rev Mol Cell Biol. 2006 Feb;7(2):131-42 PMID: 16493418
  69. Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism.
    Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3639-44 PMID: 16537448
  70. Apical targeting of syntaxin 3 is essential for epithelial cell polarity.
    J Cell Biol. 2006 Jun 19;173(6):937-48 PMID: 16785322
  71. Endothelial tubes assemble from intracellular vacuoles in vivo.
    Nature. 2006 Jul 27;442(7101):453-6 PMID: 16799567
  72. Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz.
    Nature. 2006 Aug 3;442(7102):580-4 PMID: 16862128
  73. Nucleotide exchange factor ECT2 regulates epithelial cell polarity.
    Cell Signal. 2006 Oct;18(10):1604-15 PMID: 16495035
  74. Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells.
    Nat Cell Biol. 2006 Sep;8(9):963-70 PMID: 16921364
  75. A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.
    Gastroenterology. 2006 Sep;131(3):830-40 PMID: 16952552
  76. Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development.
    Dev Dyn. 2007 Oct;236(10):2767-78 PMID: 17849438
  77. The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity.
    Curr Biol. 2007 Oct 9;17(19):1623-34 PMID: 17825562
  78. The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.
    Oncogene. 2007 Oct 25;26(49):6979-88 PMID: 17486063
  79. Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells.
    Mol Biol Cell. 2007 Nov;18(11):4483-92 PMID: 17761530
  80. The PAR proteins: fundamental players in animal cell polarization.
    Dev Cell. 2007 Nov;13(5):609-22 PMID: 17981131
  81. Depletion of apical transport proteins perturbs epithelial cyst formation and ciliogenesis.
    J Cell Sci. 2008 Apr 15;121(Pt 8):1193-203 PMID: 18349078
  82. Cell polarity and cancer--cell and tissue polarity as a non-canonical tumor suppressor.
    J Cell Sci. 2008 Apr 15;121(Pt 8):1141-50 PMID: 18388309
  83. PATJ regulates tight junction formation and polarity in mammalian epithelial cells.
    J Cell Biol. 2005 Feb 28;168(5):705-11 PMID: 15738264
  84. Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling.
    Development. 2005 Apr;132(7):1675-86 PMID: 15743877
  85. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.
    Science. 2005 Mar 11;307(5715):1603-9 PMID: 15761148
  86. Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells.
    J Cell Biol. 2005 May 23;169(4):635-46 PMID: 15897260
  87. The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program.
    Cancer Res. 2005 Jul 15;65(14):6237-44 PMID: 16024625
  88. Regulation of cadherin-mediated adhesion in morphogenesis.
    Nat Rev Mol Cell Biol. 2005 Aug;6(8):622-34 PMID: 16025097
  89. The Drosophila Dead end Arf-like3 GTPase controls vesicle trafficking during tracheal fusion cell morphogenesis.
    Dev Biol. 2007 Nov 15;311(2):487-99 PMID: 17919535
  90. Orchestrating size and shape during morphogenesis.
    Nature. 2007 Nov 8;450(7167):189-92 PMID: 17994084
  91. EGFR and beta1 integrins utilize different signaling pathways to activate Akt.
    Exp Cell Res. 2008 Jan 15;314(2):309-16 PMID: 17910952
  92. Vascular stenosis: biology and interventions.
    Curr Opin Nephrol Hypertens. 2007 Nov;16(6):516-22 PMID: 18089964
  93. Constitutive PtdIns(3,4,5)P3 synthesis promotes the development and survival of early mammalian embryos.
    Development. 2008 Feb;135(3):425-9 PMID: 18094023
  94. Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2.
    BMC Cell Biol. 2007;8:49 PMID: 18028534
  95. Navigating through models of chemotaxis.
    Curr Opin Cell Biol. 2008 Feb;20(1):35-40 PMID: 18207721
  96. Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.
    Dev Cell. 2008 Feb;14(2):205-15 PMID: 18267089
  97. The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase.
    Dev Cell. 2008 Feb;14(2):216-26 PMID: 18267090
  98. aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region.
    Biochem Biophys Res Commun. 2008 Apr 4;368(2):249-55 PMID: 18230334
  99. A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition.
    Genes Dev. 2008 Mar 15;22(6):756-69 PMID: 18347095
  100. Intrinsic epithelial cells repair the kidney after injury.
    Cell Stem Cell. 2008 Mar 6;2(3):284-91 PMID: 18371453
  101. Complex cell rearrangements during intersegmental vessel sprouting and vessel fusion in the zebrafish embryo.
    Dev Biol. 2008 Apr 15;316(2):312-22 PMID: 18342303
  102. Junctional adhesion molecule-a participates in the formation of apico-basal polarity through different domains.
    Exp Cell Res. 2006 Oct 15;312(17):3389-403 PMID: 16919624
  103. The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina.
    Dev Cell. 2006 Oct;11(4):483-93 PMID: 17011488
  104. Tight junctions and cell polarity.
    Annu Rev Cell Dev Biol. 2006;22:207-35 PMID: 16771626
  105. Phosphoinositides in cell regulation and membrane dynamics.
    Nature. 2006 Oct 12;443(7112):651-7 PMID: 17035995
  106. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control.
    Nat Cell Biol. 2006 Nov;8(11):1235-45 PMID: 17060907
  107. Simulating properties of in vitro epithelial cell morphogenesis.
    PLoS Comput Biol. 2006 Oct 6;2(10):e129 PMID: 17029556
  108. The Scribble and Par complexes in polarity and migration: friends or foes?
    Trends Cell Biol. 2006 Dec;16(12):622-30 PMID: 17067797
  109. A pump-independent function of the Na,K-ATPase is required for epithelial junction function and tracheal tube-size control.
    Development. 2007 Jan;134(1):147-55 PMID: 17164420
  110. Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2.
    Science. 2007 Jan 19;315(5810):384-6 PMID: 17234948
  111. PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.
    Cell. 2007 Jan 26;128(2):383-97 PMID: 17254974
  112. Tissue/planar cell polarity in vertebrates: new insights and new questions.
    Development. 2007 Feb;134(4):647-58 PMID: 17259302
  113. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.
    Dev Cell. 2007 Feb;12(2):221-34 PMID: 17276340
  114. Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane.
    J Cell Biol. 2007 Apr 9;177(1):21-7 PMID: 17403925
  115. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.
    Mol Biol Cell. 2007 May;18(5):1693-700 PMID: 17332496
  116. Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis.
    Mol Biol Cell. 2007 May;18(5):1943-52 PMID: 17344479
  117. Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors.
    J Cell Biol. 2007 May 21;177(4):659-69 PMID: 17517962
  118. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Nat Rev Cancer. 2007 Jun;7(6):415-28 PMID: 17508028
  119. Establishment of three-dimensional cultures of human pancreatic duct epithelial cells.
    Biochem Biophys Res Commun. 2007 Jul 6;358(3):698-703 PMID: 17512909
  120. TGF-beta in renal injury and disease.
    Semin Nephrol. 2007 May;27(3):309-20 PMID: 17533008
  121. Cellular and molecular mechanisms of border cell migration analyzed using time-lapse live-cell imaging.
    Dev Cell. 2007 Jun;12(6):997-1005 PMID: 17543870
  122. Planar polarity and tissue morphogenesis.
    Cell. 2007 Jun 15;129(6):1051-63 PMID: 17574020
  123. Synapses: sites of cell recognition, adhesion, and functional specification.
    Annu Rev Biochem. 2007;76:267-94 PMID: 17506641
  124. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis.
    J Cell Sci. 2007 Jul 15;120(Pt 14):2309-17 PMID: 17606986
  125. The Rab8 GTPase regulates apical protein localization in intestinal cells.
    Nature. 2007 Jul 19;448(7151):366-9 PMID: 17597763
  126. Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis.
    Nat Rev Mol Cell Biol. 2007 Aug;8(8):633-44 PMID: 17643125
  127. Genetic control of single lumen formation in the zebrafish gut.
    Nat Cell Biol. 2007 Aug;9(8):954-60 PMID: 17632505
  128. Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila.
    Dev Cell. 2007 Aug;13(2):214-25 PMID: 17681133
  129. Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic.
    Nat Cell Biol. 2007 Sep;9(9):1066-73 PMID: 17704769
  130. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis.
    Int J Biochem Cell Biol. 2007;39(11):1987-94 PMID: 17719831
  131. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells.
    EMBO Rep. 2008 Jun;9(6):582-9 PMID: 18483486
  132. The branching programme of mouse lung development.
    Nature. 2008 Jun 5;453(7196):745-50 PMID: 18463632
  133. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.
    Dev Cell. 2008 Jun;14(6):818-29 PMID: 18539112
  134. The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes.
    Oncogene. 2008 Jun 19;27(27):3875-9 PMID: 18246119
  135. Polarization of the C. elegans embryo by RhoGAP-mediated exclusion of PAR-6 from cell contacts.
    Science. 2008 Jun 27;320(5884):1771-4 PMID: 18583611
  136. Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease.
    J Am Soc Nephrol. 2008 Jul;19(7):1300-10 PMID: 18385427
  137. Building the cell: design principles of cellular architecture.
    Nat Rev Mol Cell Biol. 2008 Aug;9(8):593-602 PMID: 18648373
  138. Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.
    Dev Biol. 2008 Aug 1;320(1):278-88 PMID: 18585700
  139. Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation.
    J Cell Biol. 2008 Jul 28;182(2):241-8 PMID: 18663139
  140. Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation.
    J Cell Biol. 2008 Jul 28;182(2):249-61 PMID: 18663140
  141. EphrinB1 controls cell-cell junctions through the Par polarity complex.
    Nat Cell Biol. 2008 Aug;10(8):979-86 PMID: 18604196
  142. Modulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea.
    Nat Cell Biol. 2008 Aug;10(8):964-70 PMID: 18641639
  143. Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis.
    Am J Physiol Cell Physiol. 2008 Aug;295(2):C545-56 PMID: 18579802
  144. Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment.
    J Biol Chem. 2008 Aug 22;283(34):23440-9 PMID: 18550519
  145. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
    EMBO Rep. 2008 Sep;9(9):923-9 PMID: 18660750
  146. DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila.
    Genes Dev. 1998 Jan 15;12(2):274-84 PMID: 9436986
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2523
Email
david.bryant@ucsf.edu
Published
2008-11-00
Pages
887-901
Language
English
Region
England
NLM ID
100962782
PMCID
PMC2921794
Subset
IM
Grants
NIAID NIH HHS · P01 AI053194 · United States
NIDDK NIH HHS · R01 DK074398-02 · United States
NIAID NIH HHS · P01 AI053194-06A1 · United States
NIAID NIH HHS · R37 AI025144-22 · United States
NIAID NIH HHS · R37 AI025144 · United States
NIDDK NIH HHS · R01 DK074398 · United States
Corrections
CommentIn
PMID: 25373773
External Links
PubMed source DOI: 10.1038/nrm2523 PMC Full Text View journal details
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