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PMID: 2531739 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Vacuolar proton pumps.

Journal of bioenergetics and biomembranes ·Vol. 21 ·No. 5 ·1989-10-00 ·Pages 605-20

Stone DK, Crider BP, Südhof TC, Xie XS

Abstract

Recently a new class of proton-translocating ATPases has been localized to endomembrane compartments in plant, fungal, and mammalian cells. These proton pumps are large hetero-oligomers which have an ATP hydrolytic sector that is functionally and structurally distinct from a transmembranous proton pore. Enzymatic characteristics of these proton pumps are discussed as well as the current state of knowledge regarding subunit composition and function. In addition, recent primary sequence data are discussed which indicate that these proton pumps share a common ancestor with F1F0-type proton pumps of mitochondria.

MeSH Terms
Animals Intracellular Membranes/enzymology Macromolecular Substances Proton-Translocating ATPases/classification,metabolism Vacuoles/enzymology
Chemicals
Macromolecular Substances Proton-Translocating ATPases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Stone D K
Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235.
Crider B P
Südhof T C
Xie X S
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48 references, click to expand
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Article Info
Journal
Journal of bioenergetics and biomembranes
Abbr.
J Bioenerg Biomembr
ISSN
0145-479X
DOI
10.1007/BF00808116
Published
1989-10-00
Pages
605-20
Language
English
Region
United States
NLM ID
7701859
Subset
IM
Grants
NIDDK NIH HHS · DK33627 · United States
External Links
PubMed source DOI: 10.1007/BF00808116 View journal details
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