Home LiteratureArticle Details
PMID: 25248036 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

Nature communications ·Vol. 4 ·2014-09-23 ·Pages 4999

Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, Kar S, Hillman KM, Kaufmann S, Glubb DM, Beesley J, Dennis J, Bolla MK, Wang Q, Dicks E, Guo Q, Schmidt MK, Shah M, Luben R, Brown J, Czene K, Darabi H, Eriksson M, Klevebring D, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Lambrechts D, Thienpont B, Neven P, Wildiers H, Broeks A, Van't Veer LJ, Th Rutgers EJ, Couch FJ, Olson JE, Hallberg E, Vachon C, Chang-Claude J, Rudolph A, Seibold P, Flesch-Janys D, Peto J, Dos-Santos-Silva I, Gibson L, Nevanlinna H, Muranen TA, Aittomäki K, Blomqvist C, Hall P, Li J, Liu J, Humphreys K, Kang D, Choi JY, Park SK, Noh DY, Matsuo K, Ito H, Iwata H, Yatabe Y, Guénel P, Truong T, Menegaux F, Sanchez M, Burwinkel B, Marme F, Schneeweiss A, Sohn C, Wu AH, Tseng CC, Van Den Berg D, Stram DO, Benitez J, Zamora MP, Perez JI, Menéndez P, Shu XO, Lu W, Gao YT, Cai Q, Cox A, Cross SS, Reed MW, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Sawyer EJ, Tomlinson I, Kerin MJ, Miller N, Haiman CA, Henderson BE, Schumacher F, Le Marchand L, Lindblom A, Margolin S, Teo SH, Yip CH, Lee DS, Wong TY, Hooning MJ, Martens JW, Collée JM, van Deurzen CH, Hopper JL, Southey MC, Tsimiklis H, Kapuscinski MK, Shen CY, Wu PE, Yu JC, Chen ST, Alnæs GG, Borresen-Dale AL, Giles GG, Milne RL, McLean C, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Hartman M, Miao H, Buhari SA, Teo YY, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Brenner H, Dieffenbach AK, Arndt V, Stegmaier C, Swerdlow A, Ashworth A, Orr N, Schoemaker MJ, García-Closas M, Figueroa J, Chanock SJ, Lissowska J, Simard J, Goldberg MS, Labrèche F, Dumont M, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Brauch H, Brüning T, Koto YD, Radice P, Peterlongo P, Bonanni B, Volorio S, Dörk T, Bogdanova NV, Helbig S, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Devilee P, Tollenaar RA, Seynaeve C, Van Asperen CJ, Jakubowska A, Lubinski J, Jaworska-Bieniek K, Durda K, Slager S, Toland AE, Ambrosone CB, Yannoukakos D, Sangrajrang S, Gaborieau V, Brennan P, McKay J, Hamann U, Torres D, Zheng W, Long J, Anton-Culver H, Neuhausen SL, Luccarini C, Baynes C, Ahmed S, Maranian M, Healey CS, González-Neira A, Pita G, Alonso MR, Alvarez N, Herrero D, Tessier DC, Vincent D, Bacot F, de Santiago I, Carroll J, Caldas C, Brown MA, Lupien M, Kristensen VN, Pharoah PD, Chenevix-Trench G, French JD, Easton DF, Dunning AM, Australian Ovarian Cancer Management Group, Australian Ovarian Cancer Management Group

Abstract

GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotypes for a further 1,284 using 1000 Genomes Project data. All but two, strongly correlated SNPs (rs4442975 G/T and rs6721996 G/A) are excluded as candidate causal variants at odds against >100:1. The best functional candidate, rs4442975, is associated with oestrogen receptor positive (ER+) disease with an odds ratio (OR) in Europeans of 0.85 (95% confidence interval=0.84-0.87; P=1.7 × 10(-43)) per t-allele. This SNP flanks a transcriptional enhancer that physically interacts with the promoter of IGFBP5 (encoding insulin-like growth factor-binding protein 5) and displays allele-specific gene expression, FOXA1 binding and chromatin looping. Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5, a gene with known roles in breast cell biology.

MeSH Terms
Breast Neoplasms/genetics,metabolism Cell Line, Tumor Chromatin/metabolism Chromosomes, Human, Pair 2/genetics,metabolism Female Genetic Predisposition to Disease Hepatocyte Nuclear Factor 3-alpha/metabolism Humans Insulin-Like Growth Factor Binding Protein 5/genetics,metabolism MCF-7 Cells Polymorphism, Single Nucleotide Promoter Regions, Genetic/genetics RNA, Messenger/metabolism
Chemicals
Chromatin FOXA1 protein, human Hepatocyte Nuclear Factor 3-alpha Insulin-Like Growth Factor Binding Protein 5 RNA, Messenger
Authors & Affiliations
213 authors, click to expand affiliations / ORCID
Ghoussaini Maya
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Edwards Stacey L
1] Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia [2] School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Michailidou Kyriaki
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Nord Silje
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway.
Cowper-Sal Lari Richard
The Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5T 2M9.
Desai Kinjal
1] The Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5T 2M9 [2] Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755, USA.
Kar Siddhartha
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Hillman Kristine M
1] Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia [2] School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Kaufmann Susanne
1] Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia [2] School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Glubb Dylan M
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Beesley Jonathan
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Dennis Joe
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Bolla Manjeet K
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Wang Qin
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Dicks Ed
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Guo Qi
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Schmidt Marjanka K
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, 1066 CX Amsterdam, The Netherlands.
Shah Mitul
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Luben Robert
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Brown Judith
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Czene Kamila
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Darabi Hatef
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Eriksson Mikael
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Klevebring Daniel
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Bojesen Stig E
1] Copenhagen General Population Study, Herlev Hospital, 2730 Herlev, Copenhagen, Denmark [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Copenhagen, Denmark [3] Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Nordestgaard Børge G
1] Copenhagen General Population Study, Herlev Hospital, 2730 Herlev, Copenhagen, Denmark [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Copenhagen, Denmark [3] Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Nielsen Sune F
1] Copenhagen General Population Study, Herlev Hospital, 2730 Herlev, Copenhagen, Denmark [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Copenhagen, Denmark.
Flyger Henrik
Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Copenhagen, Denmark.
Lambrechts Diether
1] Laboratory for Translational Genetics, Department of Oncology, University of Leuven, 3000 Leuven, Belgium [2] Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium.
Thienpont Bernard
1] Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium [2] Vesalius Research Center, University of Leuven, 3000 Leuven, Belgium.
Neven Patrick
1] Department of Oncology, University of Leuven, 3000 Leuven, Belgium [2] Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, 3000 Leuven, Belgium.
Wildiers Hans
1] Department of Oncology, University of Leuven, 3000 Leuven, Belgium [2] Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, 3000 Leuven, Belgium.
Broeks Annegien
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, 1066 CX Amsterdam, The Netherlands.
Van't Veer Laura J
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, 1066 CX Amsterdam, The Netherlands.
Th Rutgers Emiel J
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, 1066 CX Amsterdam, The Netherlands.
Couch Fergus J
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Olson Janet E
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Hallberg Emily
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Vachon Celine
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Chang-Claude Jenny
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Rudolph Anja
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Seibold Petra
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Flesch-Janys Dieter
Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany.
Peto Julian
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Dos-Santos-Silva Isabel
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Gibson Lorna
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Nevanlinna Heli
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, FI-00029 HUS, Finland.
Muranen Taru A
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, FI-00029 HUS, Finland.
Aittomäki Kristiina
Department of Clinical Genetics, University of Helsinki, Helsinki University Central Hospital, Helsinki, FI-00029 HUS, Finland.
Blomqvist Carl
Department of Oncology, University of Helsinki, Helsinki University Central Hospital, Helsinki, FI-00029 HUS, Finland.
Hall Per
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Li Jingmei
Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
Liu Jianjun
Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
Humphreys Keith
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Kang Daehee
1] Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea [2] Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea [3] Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea.
Choi Ji-Yeob
1] Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea [2] Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea.
Park Sue K
1] Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea [2] Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea [3] Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea.
Noh Dong-Young
Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea.
Matsuo Keitaro
Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan.
Ito Hidemi
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, Japan.
Iwata Hiroji
Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya 484-8681, Japan.
Yatabe Yasushi
Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 484-8681, Japan.
Guénel Pascal
1] Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France [2] University Paris-Sud, UMRS 1018, 94807 Villejuif, France.
Truong Thérèse
1] Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France [2] University Paris-Sud, UMRS 1018, 94807 Villejuif, France.
Menegaux Florence
1] Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France [2] University Paris-Sud, UMRS 1018, 94807 Villejuif, France.
Sanchez Marie
1] Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France [2] University Paris-Sud, UMRS 1018, 94807 Villejuif, France.
Burwinkel Barbara
1] Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany [2] Molecular Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Marme Frederik
1] Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany [2] National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany.
Schneeweiss Andreas
1] Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany [2] National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany.
Sohn Christof
Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
Wu Anna H
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Tseng Chiu-Chen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Van Den Berg David
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Stram Daniel O
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Benitez Javier
1] Centro de Investigación en Red de Enfermedades Raras (CIBERER), 46010 Valencia, Spain [2] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Zamora M Pilar
Servicio de Oncología Médica, Hospital Universitario La Paz, 28046 Madrid, Spain.
Perez Jose Ignacio Arias
Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain.
Menéndez Primitiva
Servicio de Anatomía Patológica, Hospital Monte Naranco, 33013 Oviedo, Spain.
Shu Xiao-Ou
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Lu Wei
Shanghai Center for Disease Control and Prevention, Shanghai 200336, China.
Gao Yu-Tang
Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China.
Cai Qiuyin
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Cox Angela
CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK.
Cross Simon S
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Reed Malcolm W R
CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK.
Andrulis Irene L
1] Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Knight Julia A
1] Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada M5T 3M7 [2] Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
Glendon Gord
Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
Tchatchou Sandrine
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
Sawyer Elinor J
Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's &St Thomas' NHS Foundation Trust in partnership with King's College London, London SE1 9RT, UK.
Tomlinson Ian
Wellcome Trust Centre for Human Genetics, Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK.
Kerin Michael J
Clinical Science Institute, University Hospital Galway, Galway, Ireland.
Miller Nicola
Clinical Science Institute, University Hospital Galway, Galway, Ireland.
Haiman Christopher A
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Henderson Brian E
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Schumacher Fredrick
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Le Marchand Loic
Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii 96813, USA.
Lindblom Annika
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-17177, Sweden.
Margolin Sara
Department of Oncology-Pathology, Karolinska Institutet, Stockholm SE-17177, Sweden.
Teo Soo Hwang
1] Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia [2] Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya 47500 Selangor, Malaysia.
Yip Cheng Har
Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia.
Lee Daphne S C
Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya 47500 Selangor, Malaysia.
Wong Tien Y
Singapore Eye Research Institute, National University of Singapore, Singapore 168751, Singapore.
Hooning Maartje J
Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands.
Martens John W M
Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands.
Collée J Margriet
Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
van Deurzen Carolien H M
Department of Pathology, Erasmus University Medical Center, 3075 EA Rotterdam, The Netherlands.
Hopper John L
Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Southey Melissa C
Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Tsimiklis Helen
Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Kapuscinski Miroslav K
Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Shen Chen-Yang
1] College of Public Health, China Medical University, Taichung 40402, Taiwan, China [2] Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, China.
Wu Pei-Ei
Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, China.
Yu Jyh-Cherng
Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan, China.
Chen Shou-Tung
Department of Surgery, Changhua Christian Hospital, Changhua City 500, Taiwan, China.
Alnæs Grethe Grenaker
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway.
Borresen-Dale Anne-Lise
1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway [2] Institute of Clinical Medicine, University of Oslo (UiO), 0318 Oslo, Norway.
Giles Graham G
1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Milne Roger L
1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia [2] Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria 3053, Australia.
McLean Catriona
Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria 3004, Australia.
Muir Kenneth
1] Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK [2] Institute of Population Health, University of Manchester, Manchester M13 9PL, UK.
Lophatananon Artitaya
Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
Stewart-Brown Sarah
Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
Siriwanarangsan Pornthep
Ministry of Public Health, Bangkok 10400, Thailand.
Hartman Mikael
1] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore [2] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
Miao Hui
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
Buhari Shaik Ahmad Bin Syed
Division of General Surgery, National University Health System, Singapore 117597, Singapore.
Teo Yik Ying
1] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore [2] Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546, Singapore.
Fasching Peter A
1] Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA [2] Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Haeberle Lothar
Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Ekici Arif B
Institute of Human Genetics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Beckmann Matthias W
Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Brenner Hermann
1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Dieffenbach Aida Karina
1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Arndt Volker
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Stegmaier Christa
Saarland Cancer Registry, 66119 Saarbrücken, Germany.
Swerdlow Anthony
1] Division of Breast Cancer Research, Institute of Cancer Research, London SM2 5NG, UK [2] Division of Genetics and Epidemiology, Institute of Cancer Research, London SM2 5NG, UK.
Ashworth Alan
Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK.
Orr Nick
Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK.
Schoemaker Minouk J
Division of Genetics and Epidemiology, Institute of Cancer Research, London SM2 5NG, UK.
García-Closas Montserrat
1] Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK [2] Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
Figueroa Jonine
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, USA.
Chanock Stephen J
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, USA.
Lissowska Jolanta
Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland.
Simard Jacques
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec, Canada G1V 4G2.
Goldberg Mark S
1] Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 2M1 [2] Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada H3A 1A8.
Labrèche France
Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal, Montreal, Quebec, Canada H3T 1A8.
Dumont Martine
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec, Canada G1V 4G2.
Winqvist Robert
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, NordLab Oulu/Oulu University Hospital, University of Oulu, FI-90220 Oulu, Finland.
Pylkäs Katri
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, NordLab Oulu/Oulu University Hospital, University of Oulu, FI-90220 Oulu, Finland.
Jukkola-Vuorinen Arja
Department of Oncology, Oulu University Hospital, University of Oulu, FI-90220 Oulu, Finland.
Brauch Hiltrud
1] Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany [2] University of Tübingen, 72074 Tübingen, Germany [3] German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Brüning Thomas
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), 44789 Bochum, Germany.
Koto Yon-Dschun
Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany.
Radice Paolo
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.
Peterlongo Paolo
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy.
Bonanni Bernardo
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), 20141 Milan, Italy.
Volorio Sara
1] IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy [2] Cogentech Cancer Genetic Test Laboratory, 20133 Milan, Italy.
Dörk Thilo
Department of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany.
Bogdanova Natalia V
Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.
Helbig Sonja
Department of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany.
Mannermaa Arto
1] Cancer Center of Eastern Finland, University of Eastern Finland, FI-70211 Kuopio, Finland [2] Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, FI-70210 Kuopio, Finland [3] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, FI-70211 Kuopio, Finland.
Kataja Vesa
1] Cancer Center of Eastern Finland, University of Eastern Finland, FI-70211 Kuopio, Finland [2] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, FI-70211 Kuopio, Finland.
Kosma Veli-Matti
1] Cancer Center of Eastern Finland, University of Eastern Finland, FI-70211 Kuopio, Finland [2] Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, FI-70210 Kuopio, Finland [3] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, FI-70211 Kuopio, Finland.
Hartikainen Jaana M
1] Cancer Center of Eastern Finland, University of Eastern Finland, FI-70211 Kuopio, Finland [2] Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, FI-70210 Kuopio, Finland [3] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, FI-70211 Kuopio, Finland.
Devilee Peter
Department of Human Genetics &Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Tollenaar Robert A E M
Department of Surgical Oncology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Seynaeve Caroline
Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Centre, 3075 EA Rotterdam, The Netherlands.
Van Asperen Christi J
Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Jakubowska Anna
Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
Lubinski Jan
Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
Jaworska-Bieniek Katarzyna
Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
Durda Katarzyna
Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
Slager Susan
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Toland Amanda E
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.
Ambrosone Christine B
Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Yannoukakos Drakoulis
Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens 15310, Greece.
Sangrajrang Suleeporn
National Cancer Institute, Bangkok 10400, Thailand.
Gaborieau Valerie
International Agency for Research on Cancer, Lyon, Cedex 08, France.
Brennan Paul
International Agency for Research on Cancer, Lyon, Cedex 08, France.
McKay James
International Agency for Research on Cancer, Lyon, Cedex 08, France.
Hamann Ute
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Torres Diana
1] Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] Institute of Human Genetics, Pontificia University Javeriana, Bogota, DC 11001000, Colombia.
Zheng Wei
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Long Jirong
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Anton-Culver Hoda
Department of Epidemiology, University of California Irvine, Irvine, California 92697, USA.
Neuhausen Susan L
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California 92697, USA.
Luccarini Craig
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Baynes Caroline
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Ahmed Shahana
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Maranian Mel
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Healey Catherine S
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
González-Neira Anna
Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Pita Guillermo
Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Alonso M Rosario
Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Alvarez Nuria
Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Herrero Daniel
Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Tessier Daniel C
Centre d'innovation Génome Québec et Université McGill, Montréal, Quebec, Canada H3A OG1.
Vincent Daniel
McGill University, Montreal, Quebec, Canada H3A OG1.
Bacot Francois
McGill University, Montreal, Quebec, Canada H3A OG1.
de Santiago Ines
Cancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.
Carroll Jason
Cancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.
Caldas Carlos
Cancer Research UK, Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.
Brown Melissa A
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Lupien Mathieu
1] The Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5T 2M9 [2] Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [3] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7.
Kristensen Vessela N
1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway [2] Institute of Clinical Medicine, University of Oslo (UiO), 0318 Oslo, Norway [3] Department of Clinical Molecular Biology (EpiGen), University of Oslo (UiO), 0450 Oslo, Norway.
Pharoah Paul D P
1] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK [2] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Chenevix-Trench Georgia
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
French Juliet D
1] Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia [2] School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Easton Douglas F
1] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK [2] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Dunning Alison M
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Australian Ovarian Cancer Management Group
Australian Ovarian Cancer Management Group
Investigators
4 investigators, click to expand
Chenevix-Trench Georgia
Webb Penny
Bowtell David
De Fazio Anna
References (28)
28 references, click to expand
  1. Score tests for association between traits and haplotypes when linkage phase is ambiguous.
    Am J Hum Genet. 2002 Feb;70(2):425-34 PMID: 11791212
  2. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4.
    Mol Cell. 2002 Feb;9(2):279-89 PMID: 11864602
  3. IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo.
    FASEB J. 2009 Aug;23(8):2616-26 PMID: 19332648
  4. Targeting IGF-1 signaling pathways in gynecologic malignancies.
    Expert Opin Ther Targets. 2013 Mar;17(3):307-20 PMID: 23294364
  5. Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.
    Nat Genet. 2007 Jul;39(7):865-9 PMID: 17529974
  6. Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells.
    J Cell Biochem. 1999 Dec 15;75(4):652-64 PMID: 10572248
  7. Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2.
    J Biol Chem. 1997 Apr 18;272(16):10882-94 PMID: 9099745
  8. Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.
    Am J Hum Genet. 2013 Apr 4;92(4):489-503 PMID: 23540573
  9. Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo.
    J Biol Chem. 2003 Aug 8;278(32):29676-85 PMID: 12777377
  10. In vivo regulation of the insulin-like growth factor system of mitogens by human chorionic gonadotropin.
    Int J Oncol. 1998 Sep;13(3):571-5 PMID: 9683795
  11. Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state.
    Mol Syst Biol. 2011 Aug 30;7:526 PMID: 21878914
  12. Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    Nat Genet. 2013 Apr;45(4):353-61, 361e1-2 PMID: 23535729
  13. Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis.
    Biochem J. 2006 Apr 1;395(1):1-19 PMID: 16526944
  14. Genotyping with TaqMAMA.
    Genomics. 2004 Feb;83(2):311-20 PMID: 14706460
  15. Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.
    Am J Hum Genet. 2013 Dec 5;93(6):1046-60 PMID: 24290378
  16. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
    Nat Genet. 2013 Apr;45(4):371-84, 384e1-2 PMID: 23535731
  17. Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits.
    Genome Res. 2014 Jan;24(1):1-13 PMID: 24196873
  18. FOXA1 is a key determinant of estrogen receptor function and endocrine response.
    Nat Genet. 2011 Jan;43(1):27-33 PMID: 21151129
  19. Beyond GWASs: illuminating the dark road from association to function.
    Am J Hum Genet. 2013 Nov 7;93(5):779-97 PMID: 24210251
  20. Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression.
    Nat Genet. 2012 Nov;44(11):1191-8 PMID: 23001124
  21. Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers.
    Chin J Cancer. 2012 Jun;31(6):266-80 PMID: 22313597
  22. Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice.
    Development. 2002 Oct;129(19):4547-57 PMID: 12223411
  23. Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
    J Natl Cancer Inst. 2009 Jul 15;101(14):1012-8 PMID: 19567422
  24. The ENCODE (ENCyclopedia Of DNA Elements) Project.
    Science. 2004 Oct 22;306(5696):636-40 PMID: 15499007
  25. Insulin-like growth factor binding proteins in human breast cancer tissue.
    Cancer Res. 1992 Oct 1;52(19):5204-7 PMID: 1382838
  26. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
    Nature. 2012 Apr 18;486(7403):346-52 PMID: 22522925
  27. Multiple loci with different cancer specificities within the 8q24 gene desert.
    J Natl Cancer Inst. 2008 Jul 2;100(13):962-6 PMID: 18577746
  28. IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells.
    J Cell Sci. 2012 Apr 1;125(Pt 7):1693-705 PMID: 22328518
Article Info
Journal
Nature communications
Abbr.
Nat Commun
ISSN
2041-1723
Published
2014-09-23
Epub
2014-00-23
Pages
4999
Language
English
Region
England
NLM ID
101528555
PMCID
PMC4321900
Subset
IM
Grants
NCI NIH HHS · R01 CA176785 · United States
NCI NIH HHS · P30 CA016056 · United States
NCI NIH HHS · UM1 CA164920 · United States
NCI NIH HHS · R01 CA155004 · United States
NCI NIH HHS · R37 CA070867 · United States
Cancer Research UK · 11022 · United Kingdom
NCI NIH HHS · R01 CA100374 · United States
NCI NIH HHS · U01 CA116167 · United States
NCI NIH HHS · R01 CA128978 · United States
NCI NIH HHS · R01 CA064277 · United States
NCI NIH HHS · P50 CA116201 · United States
Wellcome Trust · 090532 · United Kingdom
NCI NIH HHS · U19 CA148065 · United States
Cancer Research UK · 10124 · United Kingdom
NCI NIH HHS · R01 CA116167 · United States
NCI NIH HHS · R01 CA148667 · United States
Cancer Research UK · C1287/A12014 · United Kingdom
NCI NIH HHS · R01 CA063464 · United States
NCI NIH HHS · U01 CA063464 · United States
NCI NIH HHS · R01 CA077398 · United States
NCI NIH HHS · R01 CA054281 · United States
NCI NIH HHS · R01 CA132839 · United States
NCI NIH HHS · P30 CA068485 · United States
NCI NIH HHS · R01 CA160565 · United States
Cancer Research UK · 15602 · United Kingdom
NCI NIH HHS · U01 CA098758 · United States
NCI NIH HHS · N01 CN025403 · United States
NCI NIH HHS · UM1 CA182910 · United States
Cancer Research UK · 10118 · United Kingdom
Cancer Research UK · C1287/A10118 · United Kingdom
NCI NIH HHS · R37 CA054281 · United States
Corrections
ErratumIn
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com