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PMID: 2523852 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetics of the quantitative Lp(a) lipoprotein trait. III. Contribution of Lp(a) glycoprotein phenotypes to normal lipid variation.

Human genetics ·Vol. 82 ·No. 1 ·1989-04-00 ·Pages 73-8

Boerwinkle E, Menzel HJ, Kraft HG, Utermann G

Abstract

Apolipoprotein(a) [apo(a)] is a large serum glycoprotein with several genetically determined isoforms differing in their apparent molecular weight. We determined the effects of the apo(a) isoforms on total cholesterol, high-density lipoprotein (HDL)-cholesterol, lipoprotein(a), and triglyceride levels in a sample of 473 unrelated Tyrolean adults. Average lipoprotein(a) and total cholesterol levels were significantly different among apo(a) types. These significant differences were found among the 13 apo(a) isoform patterns observed in this sample and among several logical subsets of the isoform patterns (e.g. considering only the single band types). The data suggest that the effects of apo(a) alleles on Lp(a) levels are additive. The effects of apo(a) on total cholesterol levels cannot be entirely explained by the cholesterol fraction estimated to be contained in the lipoprotein(a) particle. We estimate that the apo(a) glycoprotein polymorphism accounts for 41.9% and 9.6% of the variability in lipoprotein(a) and total cholesterol levels, respectively. This is the strongest effect of a single polymorphic gene on plasma lipid and lipoprotein levels reported so far.

MeSH Terms
Cholesterol/blood Cholesterol, HDL/blood Female Gene Frequency Humans Lipid Metabolism Lipoprotein(a) Lipoproteins/genetics,metabolism Male Phenotype Triglycerides/blood
Chemicals
Cholesterol, HDL Lipoprotein(a) Lipoproteins Triglycerides Cholesterol
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Boerwinkle E
Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston.
Menzel H J
Kraft H G
Utermann G
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00288277
Published
1989-04-00
Pages
73-8
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00288277 View journal details
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