Bias of the contribution of single-locus effects to the variance of a quantitative trait.
Advances in our understanding of the physiology of many quantitative phenotypes combined with better measurement abilities is providing a means for pursuing a measured genotype approach to partitioning the phenotypic variance into the contribution of separate loci. The standard estimate of the contribution of a single locus to the phenotypic variance applied recently in the human genetics literature is a biased statistic. We compare the biased estimates from several published studies with biased corrected estimates to illustrate the general problem.
14 references, click to expand
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