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PMID: 2521477 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6.

Human genetics ·Vol. 81 ·No. 2 ·1989-01-00 ·Pages 149-52

Lindahl G, Gersdorf E, Menzel HJ, Duba C, Cleve H, Humphries S, Utermann G

Abstract

We have studied the segregation of the Lp(a) glycoprotein phenotypes and of the plasminogen (PLG) polymorphism in three two-generation families. The inheritance of the Lp(a) gene was followed using the Lp(a) glycoprotein size polymorphism and that of the plasminogen gene, using protein and DNA polymorphisms. In the three families studied, no recombination was observed in 18 meioses. The lod score for linkage between the Lp(a) glycoprotein locus and the plasminogen locus in these families is greater than 5.0 at a recombination fraction of theta = 0. Our results show that the structural gene for the Lp(a) glycoprotein is closely linked to the gene for plasminogen on chromosome 6.

MeSH Terms
Chromosomes, Human, Pair 6 Female Genes Genetic Linkage Genetic Markers Humans Lipoprotein(a) Lipoproteins/genetics Male Pedigree Phenotype Plasminogen/genetics
Chemicals
Genetic Markers Lipoprotein(a) Lipoproteins Plasminogen
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Lindahl G
Charing Cross Sunley Research Centre, Hammersmith, London, UK.
Gersdorf E
Menzel H J
Duba C
Cleve H
Humphries S
Utermann G
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00293891
Published
1989-01-00
Pages
149-52
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00293891 View journal details
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