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PMID: 25152705 Published · ppublish English Journal Article

Metastasis-Initiating Cells in Renal Cancer.

Current signal transduction therapy ·Vol. 8 ·No. 3 ·2014-12-00 ·Pages 240-246

Khan MI, Czarnecka AM, Duchnowska R, Kukwa W, Szczylik C

Abstract

Metastasis is a complex process that propagates cells from the primary or initial site of the cancer occurrence to distant parts of the body. Cancer cells break from the cancer site and circulate through the bloodstream or lymph vessels, allowing them to reach nearly all parts of the body. These circulating tumour cells (CTCs) contain specialized metastasis-initiating cells (MICs) that reside in the biological heterogeneous primary tumour. Researchers have hypothesized that metastasis of renal cell carcinoma is initiated by circulation of MICs in patients' blood and bone marrow. Based on the cancer stem/progenitor cell concept of carcinogenesis, understanding the molecular phenotypes of metastasis-initiating cells (MICs) in renal cancer could play a vital role in developing strategies for therapeutic interventions in renal cancer. Existence of MICs among CTCs in renal carcinoma has not been proven in large scale. However, some studies have reported that specialized markers are found on the surface of circulating cells from the primary tumour. In mice, MICs have been isolated from CTCs using such markers, which have then been transplanted into xenograft model to show whether they give rise to metastasis in different organs. Considering these findings, in this review we have attempted to summarize the studies connected with MICs and their gene expression profiles that are responsible for metastasis in renal cancer.

Keywords
Circulating tumour cells metastasis-initiating cells renal cell carcinoma tumour-initiating cells.
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Khan Mohammed I
Molecular Oncology Laboratory, Clinic of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141 Warsaw, Poland.
Czarnecka Anna M
Molecular Oncology Laboratory, Clinic of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141 Warsaw, Poland.
Duchnowska Renata
Molecular Oncology Laboratory, Clinic of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141 Warsaw, Poland.
Kukwa Wojciech
Department of Otolaryngology, Czerniakowski Hospital, Medical University of Warsaw, ul. Stepinska 19/25, Warsaw, Poland.
Szczylik Cezary
Molecular Oncology Laboratory, Clinic of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141 Warsaw, Poland.
Conflict of Interest

The authors indicate no potential conflict of interest.

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Article Info
Journal
Current signal transduction therapy
Abbr.
Curr Signal Transduct Ther
ISSN
1574-3624
DOI
10.2174/1574362409666140206222431
Published
2014-12-00
Pages
240-246
Language
English
Region
United Arab Emirates
NLM ID
101273157
PMCID
PMC4141324
External Links
PubMed source DOI: 10.2174/1574362409666140206222431 PMC Full Text View journal details
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