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PMID: 21647312 Published · ppublish English Journal Article

Resident stem cells and renal carcinoma.

International journal of nephrology ·Vol. 2011 ·2011-00-00 ·Pages 286985

Bussolati B, Brossa A, Camussi G

Abstract

According to the cancer stem cell hypothesis tumors are maintained by a cancer stem cell population which is able to initiate and maintain tumors. Tumor-initiating stem cells display stem or progenitor cell properties such as self-renewal and capacity to re-establish tumors that recapitulate the tumor of origin. In this paper, we discuss data relative to the presence of cancer stem cells in human renal carcinoma and their possible origin from normal resident stem cells. The cancer stem cells identified in human renal carcinomas are not derived from the normal CD133(+) progenitors of the kidney, but rather from a more undifferentiated population that retains a mesenchymal phenotype. This population is able to self-renewal, clonogenicity, and in vivo tumor initiation. Moreover, they retain pluripotent differentiation capability, as they can generate not only the epithelial component of the tumor, but also tumor endothelial cells. This suggests that renal cancer stem cells may contribute to the intratumor vasculogenesis.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bussolati Benedetta
Laboratory of Renal and Vascular Physiopathology, Department of Internal Medicine, Molecular Biotechnology Centre and Research Centre for Molecular Medicine, University of Turin, Cso Dogliotti 14, 10126 Turin, Italy.
Brossa Alessia
Camussi Giovanni
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Article Info
Journal
International journal of nephrology
Abbr.
Int J Nephrol
ISSN
2090-2158
DOI
10.4061/2011/286985
Published
2011-00-00
Epub
2011-00-11
Pages
286985
Language
English
Region
United States
NLM ID
101546753
PMCID
PMC3106374
External Links
PubMed source DOI: 10.4061/2011/286985 PMC Full Text View journal details
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