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PMID: 2506436 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

DNA binding of the mouse class II major histocompatibility CCAAT factor depends on two components.

Molecular and cellular biology ·Vol. 9 ·No. 7 ·1989-07-00 ·Pages 3097-100

Celada A, Maki RA

Abstract

A CCAAT-binding factor that recognizes a CCAAT sequence (Y box) located upstream of the major histocompatibility class II gene I-A beta has been partially purified. This CCAAT-binding factor was found to consist of two components, designated factors A and B, both of which were required for efficient binding to the DNA. Factor A had an apparent molecular size of 34 kilodaltons, and factor B had an apparent molecular size of 42 to 46 kilodaltons.

MeSH Terms
Animals Base Sequence CCAAT-Enhancer-Binding Proteins Chromatography/methods DNA/metabolism DNA-Binding Proteins/isolation & purification,metabolism Electrophoresis, Polyacrylamide Gel Genes, MHC Class II Mice Molecular Weight Sulfuric Acid Esters Transcription Factors/genetics,metabolism
Chemicals
CCAAT-Enhancer-Binding Proteins DNA-Binding Proteins Sulfuric Acid Esters Transcription Factors DNA dimethyl sulfate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Celada A
La Jolla Cancer Research Foundation, California 92037.
Maki R A
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33 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.9.7.3097-3100.1989
Published
1989-07-00
Pages
3097-100
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC362780
Subset
IM
Grants
NIAID NIH HHS · AI 20194 · United States
External Links
PubMed source DOI: 10.1128/mcb.9.7.3097-3100.1989 PMC Full Text View journal details
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