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PMID: 2504580 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Characterization of junD: a new member of the jun proto-oncogene family.

The EMBO journal ·Vol. 8 ·No. 5 ·1989-05-00 ·Pages 1433-9

Hirai SI, Ryseck RP, Mechta F, Bravo R, Yaniv M

Abstract

In an extensive screen of a cDNA library prepared from serum-stimulated mouse NIH 3T3 cells, we identified three distinct jun-related clones. Two of them were carrying c-jun and junB sequences respectively, whereas the sequence of the third group of clones (junD) was distinct from these two and from v-jun. The amino acid sequences derived from these jun-related clones are very well conserved in five distinct regions including the putative DNA binding domain. Truncated c-Jun and JunD proteins containing the C-terminus recognize the same DNA sequences which were defined as the PEA1/AP1 binding sequence or TPA response element (TRE). Furthermore, both can trans-activate a promoter including the TRE, and this activation is further enhanced by c-fos. Contrary to c-jun and junB transcription, which are strongly stimulated by serum or TPA treatment of quiescent 3T3 cells, junD transcription is not significantly stimulated in these conditions. The tissue distribution and levels of expression of junD mRNA differ from that of c-jun and junB mRNA. These observations suggest that each of these Jun-related gene products has a distinct role in the control of gene activity and growth in the organism.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA/genetics DNA-Binding Proteins/genetics,metabolism Mice Molecular Sequence Data Promoter Regions, Genetic Proto-Oncogene Proteins c-jun Proto-Oncogenes Sequence Homology, Nucleic Acid Tissue Distribution Transcription Factors/genetics,metabolism
Chemicals
DNA-Binding Proteins Proto-Oncogene Proteins c-jun Transcription Factors DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hirai S I
Départment de Biologie Moléculaire, CNRS, Institut Pasteur, Paris, France.
Ryseck R P
Mechta F
Bravo R
Yaniv M
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1989-05-00
Pages
1433-9
Language
English
Region
England
NLM ID
8208664
PMCID
PMC400971
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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