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PMID: 2498950 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Self-administration of cocaine on a progressive ratio schedule in rats: dose-response relationship and effect of haloperidol pretreatment.

Psychopharmacology ·Vol. 97 ·No. 4 ·1989-00-00 ·Pages 535-8

Roberts DC, Loh EA, Vickers G

Abstract

Intravenous cocaine self-administration behavior in rats was investigated using a progressive ratio (PR) schedule of reinforcement. The first response on the lever each day produced a drug infusion, whereupon the requirements of the schedule escalated with each reinforcement until the behavior extinguished. The final ratio completed each day was found to be relatively stable, sensitive to changes in dose, and drastically reduced by pretreatment with haloperidol (0.05 mg/kg). We conclude that self-administration behavior of rats reinforced on a progressive ratio schedule can provide useful information about changes in the reinforcing efficacy of specific drugs.

MeSH Terms
Animals Cocaine/pharmacology Dose-Response Relationship, Drug Haloperidol/pharmacology Male Rats Rats, Inbred Strains Reinforcement Schedule Self Administration
Chemicals
Cocaine Haloperidol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Roberts D C
Department of Psychology, Carleton University, Ottawa, Canada.
Loh E A
Vickers G
References (19)
19 references, click to expand
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00439560
Published
1989-00-00
Pages
535-8
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00439560 View journal details
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