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PMID: 6141584 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Atypical neuroleptics increase self-administration of cocaine: an evaluation of a behavioural screen for antipsychotic activity.

Psychopharmacology ·Vol. 82 ·No. 1-2 ·1984-00-00 ·Pages 135-9

Roberts DC, Vickers G

Abstract

Several drugs have been shown to exert antipsychotic effects, yet they display an atypical profile with respect to standard neuroleptic drug screens. Low doses of traditional neuroleptics are known to increase self-administration of psychomotor stimulants; we sought to determine whether these atypical drugs would cause a comparable effect. Sulpiride, metoclopramide and thioridazine produced a dose-dependent increase in cocaine intake similar to that found for chlorpromazine, haloperidol, pimozide and flupenthixol. This effect was found to correlate (r = 0.94) with daily clinical dose. Clozapine, however, produced a dose-dependent decrease in cocaine intake. The advantages and disadvantages of using this measure as a screening procedure for neuroleptic drugs are discussed.

MeSH Terms
Animals Antipsychotic Agents/pharmacology Clozapine/pharmacology Cocaine/administration & dosage Drug Evaluation, Preclinical/methods Male Rats Rats, Inbred Strains Receptors, Dopamine/drug effects Self Administration
Chemicals
Antipsychotic Agents Receptors, Dopamine Cocaine Clozapine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Roberts D C
Vickers G
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31 references, click to expand
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00426397
Published
1984-00-00
Pages
135-9
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00426397 View journal details
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