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PMID: 2491780 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Linkage analysis of chromosome 17 markers in British and South African families with neurofibromatosis type I.

American journal of human genetics ·Vol. 44 ·No. 1 ·1989-01-00 ·Pages 38-40

Mathew CG, Thorpe K, Easton DF, Chin KS, Jadayel D, Ponder M, Moore G, Wallis CE, Slater CP, De Jong G

Abstract

Nine markers from the pericentromeric region of chromosome 17 were typed in 16 British and five South African families with neurofibromatosis type 1 (NF1). The markers--p17H8, pHHH202, and EW204--were linked to NF1 at recombination fractions less than 1%. No evidence of locus heterogeneity was detected. Inspection of recombinant events in families informative for several markers suggests that the NF1 gene is located between the markers EW301 (cen-p11.2) and EW206 (cen-q12) and possibly distal to pHHH202 (q11.2-q12).

MeSH Terms

Chromosomes, Human, Pair 17 Female Genetic Linkage Genetic Markers Humans Male Neurofibromatosis 1/genetics South Africa United Kingdom

Chemicals

Genetic Markers

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Mathew C G

Section of Human Cancer Genetics, Institute of Cancer Research, Surrey, United Kingdom.

Thorpe K

Easton D F

Chin K S

Jadayel D

Ponder M

Moore G

Wallis C E

Slater C P

De Jong G

References (13)

13 references, click to expand

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Regional mapping panel for human chromosome 17: application to neurofibromatosis type 1.
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Linkage of NF1 to 12 chromosome 17 markers: a summary of eight concurrent reports.
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Linkage analysis of British and Indian families with Von Recklinghausen neurofibromatosis.
J Med Genet. 1987 Sep;24(9):524-6 PMID: 3118029
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Article Info

Journal

American journal of human genetics

Abbr.

Am J Hum Genet

ISSN

0002-9297

Published

1989-01-00

Pages

38-40

Language

English

Region

United States

NLM ID

0370475

PMCID

PMC1715463

Subset

External Links

PubMed source PMC Full Text View journal details

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Linkage analysis of chromosome 17 markers in British and South African families with neurofibromatosis type I.

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