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PMID: 24915298 Published · ppublish English Journal Article Review

The autophagic roles of Rab small GTPases and their upstream regulators: a review.

Autophagy ·Vol. 10 ·No. 7 ·2014-07-00 ·Pages 1154-66

Szatmári Z, Sass M

Abstract

Macroautophagy is an evolutionarily conserved degradative process of eukaryotic cells. Double-membrane vesicles called autophagosomes sequester portions of cytoplasm and undergo fusion with the endolysosomal pathway in order to degrade their content. There is growing evidence that members of the small GTPase RAB protein family-the well-known regulators of membrane trafficking and fusion events-play key roles in the regulation of the autophagic process. Despite numerous studies focusing on the functions of RAB proteins in autophagy, the importance of their upstream regulators in this process emerged only in the past few years. In this review, we summarize recent advances on the effects of RABs and their upstream modulators in the regulation of autophagy. Moreover, we discuss how impairment of these proteins alters the autophagic process leading to several generally known human diseases.

Keywords
GAP GEF RAB autophagy small GTPases
MeSH Terms
Autophagy Disease Endosomes/metabolism Golgi Apparatus/metabolism Humans Models, Biological rab GTP-Binding Proteins/metabolism
Chemicals
rab GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Szatmári Zsuzsanna
Department of Anatomy, Cell and Developmental Biology; Eötvös Loránd University; Budapest, Hungary.
Sass Miklós
Department of Anatomy, Cell and Developmental Biology; Eötvös Loránd University; Budapest, Hungary.
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Article Info
Journal
Autophagy
Abbr.
Autophagy
ISSN
1554-8635
DOI
10.4161/auto.29395
Published
2014-07-00
Epub
2014-00-04
Pages
1154-66
Language
English
Region
United States
NLM ID
101265188
PMCID
PMC4203544
Subset
IM
External Links
PubMed source DOI: 10.4161/auto.29395 PMC Full Text View journal details
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