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PMID: 2473636 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Some further characteristics of histamine secretion from rat mast cells stimulated with sodium orthovanadate.

Agents and actions ·Vol. 27 ·No. 1-2 ·1989-04-00 ·Pages 65-7

al-Laith M, Pearce FL

Abstract

Sodium orthovanadate induced a release of histamine from rat peritoneal mast cells. Other oxyanions of vanadium with the metal in the +V oxidation state also evoked histamine release but neither vanadyl sulphate (+IV oxidation state) nor the analogous orthophosphate anion were effective secretagogues. The release evoked by vanadate was selectively inhibited by the anion channel blocker SITS, and by theophylline and Bu2cAMP, but was unaffected by disodium cromoglycate and lanthanum ions. These results are discussed in terms of the possible mode of action of vanadate.

MeSH Terms

4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid/pharmacology Animals Bucladesine/pharmacology Calcium/metabolism Histamine Release/drug effects In Vitro Techniques Mast Cells/drug effects,physiology Rats Rats, Inbred Strains Theophylline/pharmacology Vanadates/pharmacology

Chemicals

4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid Vanadates Bucladesine Theophylline Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

al-Laith M

Department of Chemistry, University College London, UK.

Pearce F L

References (8)

8 references, click to expand

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Br J Pharmacol. 1979 Mar;65(3):395-402 PMID: 85466
A possible role for cyclic AMP in the regulation of histamine secretion and the action of cromoglycate.
Biochem Pharmacol. 1975 Feb 15;24(4):538-40 PMID: 46148
Characteristics of histamine secretion from rat peritoneal mast cells sensitized to the nematode Nippostrongylus brasiliensis.
Immunology. 1982 Jun;46(2):353-9 PMID: 6177624
The nature of the membrane sites controlling anion permeability of human red blood cells as determined by studies with disulfonic stilbene derivatives.
J Membr Biol. 1972 Dec 29;10(3):311-30 PMID: 4667922
Histamine secretion from mast cells stimulated with sodium orthovanadate.
Agents Actions. 1988 Apr;23(3-4):168-9 PMID: 2455979
Effect of lanthanide ions on histamine secretion from rat peritoneal mast cells.
Br J Pharmacol. 1981 Feb;72 (2):341-7 PMID: 6163496
Cardiac actions of vanadium.
Fed Proc. 1983 Oct;42(13):2984-8 PMID: 6311633
The fate of cytoplasmic vanadium. Implications on (NA,K)-ATPase inhibition.
J Biol Chem. 1979 Mar 25;254(6):1781-4 PMID: 217870

Article Info

Journal

Agents and actions

Abbr.

Agents Actions

ISSN

0065-4299

DOI

10.1007/BF02222200

Published

1989-04-00

Pages

65-7

Language

English

Region

Switzerland

NLM ID

0213341

Subset

Grants

Wellcome Trust · United Kingdom

External Links

PubMed source DOI: 10.1007/BF02222200

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Some further characteristics of histamine secretion from rat mast cells stimulated with sodium orthovanadate.

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