Home LiteratureArticle Details
PMID: 2455979 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Histamine secretion from mast cells stimulated with sodium orthovanadate.

Agents and actions ·Vol. 23 ·No. 3-4 ·1988-04-00 ·Pages 168-9

al-Laith M, Pearce FL

Abstract

Sodium orthovanadate was found to be an effective histamine liberator from peritoneal mast cells of the rat and mouse. The release process was slow, non-cytotoxic and strongly dependent on pH and extracellular calcium. The effect was highly tissue and species specific and human basophil leucocytes and tissue mast cells of the rat and guinea pig were only weakly responsive or essentially unreactive.

MeSH Terms
Animals Calcium/metabolism Guinea Pigs Histamine Release/drug effects Humans In Vitro Techniques Mast Cells/drug effects,immunology,metabolism Mice Rats Rats, Inbred Strains Vanadates/pharmacology
Chemicals
Vanadates Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
al-Laith M
Department of Chemistry, University College London, UK.
Pearce F L
References (8)
8 references, click to expand
  1. The effect of alkaline earth cations on the release of histamine from rat peritoneal mast cells treated with compound 48/80 and peptide 401.
    Br J Pharmacol. 1979 Mar;65(3):395-402 PMID: 85466
  2. Vanadate stimulates rat pancreatic enzyme secretion through the release of calcium from an intracellular store.
    Cell Calcium. 1984 Aug;5(4):335-50 PMID: 6207928
  3. Calcium and histamine secretion from mast cells.
    Prog Med Chem. 1982;19:59-109 PMID: 6294742
  4. Minireview: physiological and pharmacological properties of vanadium.
    Life Sci. 1983 Oct 3;33(14):1325-40 PMID: 6312232
  5. Isolation and properties of cardiac and other mast cells from the rat and guinea-pig.
    Agents Actions. 1985 Apr;16(3-4):138-40 PMID: 2409761
  6. Cardiac actions of vanadium.
    Fed Proc. 1983 Oct;42(13):2984-8 PMID: 6311633
  7. Activation of 45Ca2+ influx and 22Na+/H+ exchange by epidermal growth factor and vanadate in A431 cells is independent of phosphatidylinositol turnover and is inhibited by phorbol ester and diacylglycerol.
    J Biol Chem. 1986 Jul 15;261(20):9321-7 PMID: 3013885
  8. Calcium efflux and histamine secretion from rat peritoneal mast cells.
    Agents Actions. 1984 Apr;14(3-4):392-6 PMID: 6203355
Article Info
Journal
Agents and actions
Abbr.
Agents Actions
ISSN
0065-4299
DOI
10.1007/BF02142530
Published
1988-04-00
Pages
168-9
Language
English
Region
Switzerland
NLM ID
0213341
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1007/BF02142530
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2