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PMID: 24621569 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions.

Cell adhesion & migration ·Vol. 8 ·No. 2 ·2014-00-00 ·Pages 125-35

Abu Taha A, Schnittler HJ

Abstract

Endothelial adherens junctions are critical for physiological and pathological processes such as differentiation, maintenance of entire monolayer integrity, and the remodeling. The endothelial-specific VE-cadherin/catenin complex provides the backbone of adherens junctions and acts in close interaction with actin filaments and actin/myosin-mediated contractility to fulfill the junction demands. The functional connection between the cadherin/catenin complex and actin filaments might be either directly through ?-catenins, or indirectly e.g., via linker proteins such as vinculin, p120ctn, ?-actinin, or EPLIN. However, both junction integrity and dynamic remodeling have to be contemporarily coordinated. The actin-related protein complex ARP2/3 and its activating molecules, such as N-WASP and WAVE, have been shown to regulate the lammellipodia-mediated formation of cell junctions in both epithelium and endothelium. Recent reports now demonstrate a novel aspect of the ARP2/3 complex and the nucleating-promoting factors in the maintenance of endothelial barrier function and junction remodeling of established endothelial cell junctions. Those mechanisms open novel possibilities; not only in fulfilling physiological demands but obtained information may be of critical importance in pathologies such as wound healing, angiogenesis, inflammation, and cell diapedesis.

Keywords
ARP2/3 complex VE-cadherin actin cortical actin endothelium stress fibers
MeSH Terms
Actin-Related Protein 2-3 Complex/genetics,metabolism Actinin/metabolism Actins/genetics,metabolism Antigens, CD/genetics,metabolism Cadherins/genetics,metabolism Catenins/metabolism Endothelium, Vascular/metabolism Humans Intercellular Junctions/genetics,metabolism Stress Fibers/metabolism Transendothelial and Transepithelial Migration/genetics Vinculin/metabolism alpha Catenin/metabolism
Chemicals
Actin-Related Protein 2-3 Complex Actins Antigens, CD Cadherins Catenins alpha Catenin cadherin 5 delta catenin Actinin Vinculin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Abu Taha Abdallah
Institute of Anatomy & Vascular Biology; WWU-Münster, Vesaliusweg 2-4; Münster, Germany.
Schnittler Hans-J
Institute of Anatomy & Vascular Biology; WWU-Münster, Vesaliusweg 2-4; Münster, Germany.
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Article Info
Journal
Cell adhesion & migration
Abbr.
Cell Adh Migr
ISSN
1933-6926
DOI
10.4161/cam.28243
Published
2014-00-00
Pages
125-35
Language
English
Region
United States
NLM ID
101469464
PMCID
PMC4049858
Subset
IM
External Links
PubMed source DOI: 10.4161/cam.28243 PMC Full Text View journal details
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