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PMID: 2456212 Published · ppublish English Comparative Study Journal Article

A model for the hepatitis B virus core protein: prediction of antigenic sites and relationship to RNA virus capsid proteins.

The EMBO journal ·Vol. 7 ·No. 3 ·1988-03-00 ·Pages 819-24

Argos P, Fuller SD

Abstract

The sequences of the core proteins from several serotypes of human hepatitis B virus and related mammalian and avian hepadnaviruses are aligned with the vp3 capsid protein of mengo virus, a picornavirus. The homology indicates an eight-stranded antiparallel beta-barrel fold for the hepatitis protein, as observed in the tertiary structure of the picornavirus protein. The locations of known antigenic sites and other modifications are consistent with this structure for the core protein. The predicted folding suggests additional exposed antigenic sites and supports an evolutionary relationship between this family of enveloped DNA viruses and enveloped and non-enveloped RNA viruses.

MeSH Terms
Capsid/analysis Epitopes Hepatitis B virus/immunology Models, Molecular Molecular Conformation Sequence Homology, Nucleic Acid Viral Core Proteins/immunology
Chemicals
Epitopes Viral Core Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Argos P
Biocomputing Programme, EMBL, Heidelberg, FRG.
Fuller S D
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48 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1988-03-00
Pages
819-24
Language
English
Region
England
NLM ID
8208664
PMCID
PMC454397
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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