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PMID: 24440914 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Regulation of autophagy by the Rab GTPase network.

Cell death and differentiation ·Vol. 21 ·No. 3 ·2014-03-00 ·Pages 348-58

Ao X, Zou L, Wu Y

Abstract

Autophagy (macroautophagy) is a highly conserved intracellular and lysosome-dependent degradation process in which autophagic substrates are enclosed and degraded by a double-membrane vesicular structure in a continuous and dynamic vesicle transport process. The Rab protein is a small GTPase that belongs to the Ras-like GTPase superfamily and regulates the vesicle traffic process. Numerous Rab proteins have been shown to be involved in various stages of autophagy. Rab1, Rab5, Rab7, Rab9A, Rab11, Rab23, Rab32, and Rab33B participate in autophagosome formation, whereas Rab9 is required in non-canonical autophagy. Rab7, Rab8B, and Rab24 have a key role in autophagosome maturation. Rab8A and Rab25 are also involved in autophagy, but their role is unknown. Here, we summarize new findings regarding the involvement of Rabs in autophagy and provide insights regarding future research on the mechanisms of autophagy regulation.

MeSH Terms
Animals Autophagy/physiology Humans rab GTP-Binding Proteins/metabolism
Chemicals
rab GTP-Binding Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ao X
The Battalion 5 of Cadet Brigade, PLA, Third Military Medical University, Chongqing, China.
Zou L
Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Wu Y
Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
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Article Info
Journal
Cell death and differentiation
Abbr.
Cell Death Differ
ISSN
1476-5403
DOI
10.1038/cdd.2013.187
Published
2014-03-00
Epub
2014-00-17
Pages
348-58
Language
English
Region
England
NLM ID
9437445
PMCID
PMC3921601
Subset
IM
External Links
PubMed source DOI: 10.1038/cdd.2013.187 PMC Full Text View journal details
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