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PMID: 20966969 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

TRAPP complexes in membrane traffic: convergence through a common Rab.

Nature reviews. Molecular cell biology ·Vol. 11 ·No. 11 ·2010-00-00 ·Pages 759-63

Barrowman J, Bhandari D, Reinisch K, Ferro-Novick S

Abstract

Transport protein particle (TRAPP; also known as trafficking protein particle), a multimeric guanine nucleotide-exchange factor for the yeast GTPase Ypt1 and its mammalian homologue, RAB1, regulates multiple membrane trafficking pathways. TRAPP complexes exist in three forms, each of which activates Ypt1 or RAB1 through a common core of subunits and regulates complex localization through distinct subunits. Whereas TRAPPI and TRAPPII tether coated vesicles during endoplasmic reticulum to Golgi and intra-Golgi traffic, respectively, TRAPPIII has recently been shown to be required for autophagy. These advances illustrate how the TRAPP complexes link Ypt1 and RAB1 activation to distinct membrane-tethering events.

MeSH Terms
Animals Carrier Proteins/genetics,metabolism Endoplasmic Reticulum/metabolism Golgi Apparatus/metabolism Guanine Nucleotide Exchange Factors/genetics,metabolism Humans Intercellular Signaling Peptides and Proteins Models, Biological Mutation Vesicular Transport Proteins/genetics,metabolism rab1 GTP-Binding Proteins/metabolism
Chemicals
Carrier Proteins Guanine Nucleotide Exchange Factors Intercellular Signaling Peptides and Proteins TRAPPC9 protein, human Vesicular Transport Proteins transport protein particle, TRAPP rab1 GTP-Binding Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Barrowman Jemima
Department of Cell Biology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.
Bhandari Deepali
Reinisch Karin
Ferro-Novick Susan
References (49)
49 references, click to expand
  1. Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion.
    Science. 2000 Jul 21;289(5478):444-8 PMID: 10903204
  2. Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles.
    Cell. 2003 Aug 22;114(4):497-509 PMID: 12941277
  3. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy.
    J Cell Biol. 2010 Jan 11;188(1):101-14 PMID: 20065092
  4. Identification of mutations in TRAPPC9, which encodes the NIK- and IKK-beta-binding protein, in nonsyndromic autosomal-recessive mental retardation.
    Am J Hum Genet. 2009 Dec;85(6):909-15 PMID: 20004765
  5. Coupled ER to Golgi transport reconstituted with purified cytosolic proteins.
    J Cell Biol. 1997 Dec 1;139(5):1097-108 PMID: 9382859
  6. Dynamics and diversity in autophagy mechanisms: lessons from yeast.
    Nat Rev Mol Cell Biol. 2009 Jul;10(7):458-67 PMID: 19491929
  7. SNARE status regulates tether recruitment and function in homotypic COPII vesicle fusion.
    J Biol Chem. 2006 Dec 15;281(50):38825-33 PMID: 17038314
  8. Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway.
    J Biol Chem. 2005 Sep 30;280(39):33669-78 PMID: 16079147
  9. Combination of linkage mapping and microarray-expression analysis identifies NF-kappaB signaling defect as a cause of autosomal-recessive mental retardation.
    Am J Hum Genet. 2009 Dec;85(6):903-8 PMID: 20004764
  10. Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins.
    EMBO J. 1998 Apr 15;17(8):2156-65 PMID: 9545229
  11. Where do they come from? Insights into autophagosome formation.
    FEBS Lett. 2010 Apr 2;584(7):1296-301 PMID: 20188731
  12. Control systems for membrane fusion in the ancestral eukaryote; evolution of tethering complexes and SM proteins.
    BMC Evol Biol. 2007 Feb 23;7:29 PMID: 17319956
  13. The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants.
    J Cell Biol. 1989 Sep;109(3):1015-22 PMID: 2504726
  14. Structure and mechanism in membrane trafficking.
    Curr Opin Cell Biol. 2010 Aug;22(4):454-60 PMID: 20418086
  15. Uso1 protein is a dimer with two globular heads and a long coiled-coil tail.
    J Struct Biol. 1996 May-Jun;116(3):356-65 PMID: 8812994
  16. Molecular architecture of the TRAPPII complex and implications for vesicle tethering.
    Nat Struct Mol Biol. 2010 Nov;17(11):1298-304 PMID: 20972447
  17. SNAREs--engines for membrane fusion.
    Nat Rev Mol Cell Biol. 2006 Sep;7(9):631-43 PMID: 16912714
  18. Vesicle tethering complexes in membrane traffic.
    J Cell Sci. 2002 Jul 1;115(Pt 13):2627-37 PMID: 12077354
  19. Long coiled-coil proteins and membrane traffic.
    Biochim Biophys Acta. 2003 Aug 18;1641(2-3):71-85 PMID: 12914949
  20. Identification and characterization of five new subunits of TRAPP.
    Eur J Cell Biol. 2000 Feb;79(2):71-80 PMID: 10727015
  21. The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery.
    Cell. 1988 Mar 25;52(6):915-24 PMID: 3127057
  22. GTP-binding Ypt1 protein and Ca2+ function independently in a cell-free protein transport reaction.
    Proc Natl Acad Sci U S A. 1990 Jan;87(1):355-9 PMID: 2104983
  23. Network organization of the human autophagy system.
    Nature. 2010 Jul 1;466(7302):68-76 PMID: 20562859
  24. Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle.
    Dev Cell. 2007 May;12(5):671-82 PMID: 17488620
  25. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23.
    Nature. 2007 Feb 22;445(7130):941-4 PMID: 17287728
  26. The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering.
    Cell. 2006 Nov 17;127(4):817-30 PMID: 17110339
  27. Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda.
    Nat Genet. 1999 Aug;22(4):400-4 PMID: 10431248
  28. A Ypt32p exchange factor is a putative effector of Ypt1p.
    Mol Biol Cell. 2002 Sep;13(9):3336-43 PMID: 12221137
  29. TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion.
    EMBO J. 1998 May 1;17(9):2494-503 PMID: 9564032
  30. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus.
    J Cell Sci. 2005 Mar 15;118(Pt 6):1209-22 PMID: 15728249
  31. Mutants in trs120 disrupt traffic from the early endosome to the late Golgi.
    J Cell Biol. 2005 Dec 5;171(5):823-33 PMID: 16314430
  32. Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells.
    FEBS Lett. 2008 Nov 12;582(27):3729-33 PMID: 18930054
  33. Rabs and their effectors: achieving specificity in membrane traffic.
    Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11821-7 PMID: 16882731
  34. The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes.
    Cell. 2008 Jun 27;133(7):1202-13 PMID: 18585354
  35. mBet3p is required for homotypic COPII vesicle tethering in mammalian cells.
    J Cell Biol. 2006 Jul 31;174(3):359-68 PMID: 16880271
  36. TRAPPC2L is a novel, highly conserved TRAPP-interacting protein.
    Traffic. 2009 Jun;10(6):724-36 PMID: 19416478
  37. The mechanisms of vesicle budding and fusion.
    Cell. 2004 Jan 23;116(2):153-66 PMID: 14744428
  38. Identification of the novel TRAPP associated protein Tca17.
    Traffic. 2009 Jun;10(6):713-23 PMID: 19220810
  39. Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae.
    Autophagy. 2005 Apr;1(1):37-45 PMID: 16874038
  40. Bi-directional protein transport between the ER and Golgi.
    Annu Rev Cell Dev Biol. 2004;20:87-123 PMID: 15473836
  41. Intracellular aspects of the process of protein synthesis.
    Science. 1975 Aug 1;189(4200):347-58 PMID: 1096303
  42. TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.
    Mol Cell. 2001 Feb;7(2):433-42 PMID: 11239471
  43. TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF.
    Nat Cell Biol. 2006 Nov;8(11):1263-9 PMID: 17041589
  44. Establishing a role for the GTPase Ypt1p at the late Golgi.
    Traffic. 2010 Apr;11(4):520-32 PMID: 20059749
  45. mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles.
    Mol Biol Cell. 2009 Oct;20(19):4205-15 PMID: 19656848
  46. TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila.
    J Cell Sci. 2009 Dec 15;122(Pt 24):4526-34 PMID: 19934220
  47. A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly.
    Am J Hum Genet. 2009 Dec;85(6):897-902 PMID: 20004763
  48. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy.
    Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7811-6 PMID: 20375281
  49. A mouse TRAPP-related protein is involved in pigmentation.
    Genomics. 2006 Aug;88(2):196-203 PMID: 16697553
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2999
Published
2010-00-00
Pages
759-63
Language
English
Region
England
NLM ID
100962782
Subset
IM
Grants
NIGMS NIH HHS · R01 GM41223 · United States
NIGMS NIH HHS · R01 GM80616 · United States
HHMI · United States
External Links
PubMed source DOI: 10.1038/nrm2999 View journal details
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