Molecular genetics of the VDAC ion channel: structural model and sequence analysis.

Journal of bioenergetics and biomembranes ·Vol. 19 ·No. 4 ·1987-08-00 ·Pages 341-50

Forte M, Guy HR, Mannella CA

Abstract

The voltage-dependent anion-selective channel of the outer mitochondrial membrane provides a unique system in which to study the molecular basis of voltage gating of ion flow. We have cloned and sequenced a cDNA coding for this protein in yeast. From the derived amino acid sequence, we have generated a preliminary model for the secondary structure of the protein which suggests that the protein forms a "beta-barrel" type structure. Comparison of the VDAC amino acid sequence with that of the bacterial porins has indicated that the two classes of molecules appear to be unrelated.

MeSH Terms

Amino Acid Sequence Base Sequence Genes Genes, Fungal Ion Channels/physiology Membrane Proteins/genetics Mitochondria/physiology Porins Saccharomyces cerevisiae/genetics Voltage-Dependent Anion Channels

Chemicals

Ion Channels Membrane Proteins Porins Voltage-Dependent Anion Channels

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Forte M

Guy H R

Mannella C A

References (24)

24 references, click to expand

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Article Info

Journal

Journal of bioenergetics and biomembranes

Abbr.

J Bioenerg Biomembr

ISSN

0145-479X

DOI

10.1007/BF00768537

Published

1987-08-00

Pages

341-50

Language

English

Region

United States

NLM ID

7701859

Subset

External Links

PubMed source DOI: 10.1007/BF00768537 View journal details

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Molecular genetics of the VDAC ion channel: structural model and sequence analysis.

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