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PMID: 24326621 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration.

Nature reviews. Molecular cell biology ·Vol. 15 ·No. 1 ·2014-01-00 ·Pages 19-33

Barker N

Abstract

Small populations of adult stem cells are responsible for the remarkable ability of the epithelial lining of the intestine to be efficiently renewed and repaired throughout life. The recent discovery of specific markers for these stem cells, together with the development of new technologies to track endogenous stem cell activity in vivo and to exploit their ability to generate new epithelia ex vivo, has greatly improved our understanding of stem cell-driven homeostasis, regeneration and cancer in the intestine. These exciting new insights into the biology of intestinal stem cells have the potential to accelerate the development of stem cell-based therapies and ameliorate cancer treatments.

MeSH Terms
Adult Stem Cells/physiology Animals Cell Lineage Epithelial Cells/physiology Homeostasis Humans Intestinal Mucosa/cytology,physiology Models, Biological Regeneration Stem Cell Niche
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Barker Nick
A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore. MRC Centre for Regenerative Medicine, The University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596 Singapore.
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm3721
Published
2014-01-00
Epub
2013-00-11
Pages
19-33
Language
English
Region
England
NLM ID
100962782
Subset
IM
External Links
PubMed source DOI: 10.1038/nrm3721 View journal details
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