Immortal strands? Give me a break.

Cell ·Vol. 129 ·No. 7 ·2007-06-29 ·Pages 1244-7

Lansdorp PM

Abstract

The "immortal strand" hypothesis proposes that asymmetrically dividing stem cells selectively retain chromosomes containing "old" DNA to prevent accumulation of mutations. As I describe in this Essay, such a possibility seems unlikely. An alternative explanation is that asymmetric cell divisions and cell fate are codirected by epigenetic differences between sister chromatids.

MeSH Terms

Animals Cell Division/genetics Chromosome Segregation/genetics DNA Breaks, Single-Stranded DNA Repair/genetics DNA Replication/genetics Epigenesis, Genetic/genetics Humans RNA Interference/physiology Sister Chromatid Exchange/genetics Stem Cells/metabolism

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Lansdorp Peter M

Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada. plansdor@bccrc.ca

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2007.06.017

plansdor@bccrc.ca

Published

2007-06-29

Pages

1244-7

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/j.cell.2007.06.017 View journal details

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