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PMID: 2428613 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Coordination of murine parotid secretory protein and salivary amylase expression.

The EMBO journal ·Vol. 5 ·No. 8 ·1986-08-00 ·Pages 1891-6

Poulsen K, Jakobsen BK, Mikkelsen BM, Harmark K, Nielsen JT, Hjorth JP

Abstract

PSP, parotid secretory protein, and salivary amylase are the major secretory proteins of mouse parotid gland where they appear in a constant ratio. Here we describe the isolation of the PSP gene and show through expression analysis on this and the salivary amylase gene that the two genes are transcribed in a coordinate fashion in adult animals, whereas the activation profiles are different during postnatal development. An explanation is put forward that involves activation of the genes at different stages of the acinar cell differentiation, leading in adults to the maximal and thus proportionate expression.

MeSH Terms
Amylases/genetics Animals Bacteriophage lambda/genetics Base Sequence Cloning, Molecular Genes/drug effects Isoproterenol/pharmacology Mice Mice, Inbred C3H Mice, Inbred Strains Nucleic Acid Hybridization RNA, Messenger/genetics Saliva/enzymology Salivary Proteins and Peptides/genetics Species Specificity Transcription, Genetic
Chemicals
Bpifa2 protein, mouse RNA, Messenger Salivary Proteins and Peptides Amylases Isoproterenol
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Poulsen K
Jakobsen B K
Mikkelsen B M
Harmark K
Nielsen J T
Hjorth J P
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1986-08-00
Pages
1891-6
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1167055
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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