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PMID: 24091060 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

The intimate relationships of mRNA decay and translation.

Trends in genetics : TIG ·Vol. 29 ·No. 12 ·2013-12-00 ·Pages 691-9

Roy B, Jacobson A

Abstract

The decay rate of an mRNA and the efficiency with which it is translated are key determinants of eukaryotic gene expression. Although it was once thought that mRNA stability and translational efficiency were directly linked, the interrelationships between the two processes are considerably more complex. The decay of individual mRNAs can be triggered or antagonized by translational impairment, and alterations in the half-life of certain mRNAs can even alter translational fidelity. In this review we consider whether mRNA translation and turnover are distinct or overlapping phases of an mRNA life cycle, and then address some of the many ways in which the two processes influence each other in eukaryotic cells.

Keywords
mRNA degradation quality control translational repression
MeSH Terms
Protein Biosynthesis RNA, Messenger/genetics
Chemicals
RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Roy Bijoyita
Department of Microbiology and Physiological Systems, Albert Sherman Center, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA.
Jacobson Allan
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Article Info
Journal
Trends in genetics : TIG
Abbr.
Trends Genet
ISSN
0168-9525
DOI
10.1016/j.tig.2013.09.002
Published
2013-12-00
Epub
2013-00-30
Pages
691-9
Language
English
Region
England
NLM ID
8507085
PMCID
PMC3854950
Subset
IM
Grants
NIGMS NIH HHS · R01 GM027757 · United States
NIGMS NIH HHS · R37 GM027757 · United States
External Links
PubMed source DOI: 10.1016/j.tig.2013.09.002 PMC Full Text View journal details
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