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PMID: 23580283 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Colorectal cancer: looking for answers in the microbiota.

Cancer discovery ·Vol. 3 ·No. 4 ·2013-04-00 ·Pages 384-7

Jobin C

Abstract

At a simplistic level, colorectal cancer arises from mutations in various proto-oncogenes and tumor suppressor genes. Aside from genetically inherited factors, environmental, lifestyle, and dietary habits have all been identified as risk agents promoting mutational events leading to the development of colorectal cancer. This "In Focus" presents evidence that the intestinal endogenous bacterial community represents a risk factor for the development of colorectal cancer.

MeSH Terms
Animals Colorectal Neoplasms/metabolism,microbiology Humans Intestines/microbiology Metagenome Receptors, Pattern Recognition/metabolism
Chemicals
Receptors, Pattern Recognition
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Jobin Christian
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA. job@med.unc.edu
References (15)
15 references, click to expand
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Article Info
Journal
Cancer discovery
Abbr.
Cancer Discov
ISSN
2159-8290
DOI
10.1158/2159-8290.CD-13-0042
Email
job@med.unc.edu
Published
2013-04-00
Pages
384-7
Language
English
Region
United States
NLM ID
101561693
PMCID
PMC3625977
Subset
IM
Grants
NIDDK NIH HHS · R01 DK073338 · United States
NIDDK NIH HHS · DK047700 · United States
NIDDK NIH HHS · R01 DK047700 · United States
NIDDK NIH HHS · DK073338 · United States
NIDDK NIH HHS · R56 DK047700 · United States
External Links
PubMed source DOI: 10.1158/2159-8290.CD-13-0042 PMC Full Text View journal details
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