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PMID: 23545416 Published · epublish English Journal Article Review

Caspase functions in cell death and disease.

Cold Spring Harbor perspectives in biology ·Vol. 5 ·No. 4 ·2013-04-01 ·Pages a008656

McIlwain DR, Berger T, Mak TW

Abstract

Caspases are a family of endoproteases that provide critical links in cell regulatory networks controlling inflammation and cell death. The activation of these enzymes is tightly controlled by their production as inactive zymogens that gain catalytic activity following signaling events promoting their aggregation into dimers or macromolecular complexes. Activation of apoptotic caspases results in inactivation or activation of substrates, and the generation of a cascade of signaling events permitting the controlled demolition of cellular components. Activation of inflammatory caspases results in the production of active proinflammatory cytokines and the promotion of innate immune responses to various internal and external insults. Dysregulation of caspases underlies human diseases including cancer and inflammatory disorders, and major efforts to design better therapies for these diseases seek to understand how these enzymes work and how they can be controlled.

MeSH Terms
Animals Apoptosis Caspases/metabolism,physiology Cell Death Dimerization Gene Expression Regulation Humans Immunity, Innate Inflammation Mice Necrosis Neoplasms/metabolism Signal Transduction Toll-Like Receptors
Chemicals
Toll-Like Receptors Caspases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
McIlwain David R
The Campbell Family Institute for Breast Cancer Research and Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada.
Berger Thorsten
Mak Tak W
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a008656
Published
2013-04-01
Epub
2013-00-01
Pages
a008656
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC3683896
Subset
IM
Corrections
ErratumIn
PMID: 25833847
External Links
PubMed source DOI: 10.1101/cshperspect.a008656 PMC Full Text View journal details
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