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PMID: 19531679 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology ·Vol. 18 ·No. 7 ·2009-07-00 ·Pages 2114-22

Xu HL, Xu WH, Cai Q, Feng M, Long J, Zheng W, Xiang YB, Shu XO

Abstract

Caspase-3, caspase-7, and caspase-8 are important caspases in the apoptosis pathway and play an important role in the development and progression of cancer. We examined the association between genetic variants in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer among Chinese women. Genotypes for 1,028 women with endometrial cancer and 1,003 healthy controls were determined with the Affymetrix MegAllele Targeted Genotyping System and Molecular Inversion Probe method. Of 35 selected single-nucleotide polymorphisms, four in the caspase-7 gene were in high linkage disequilibrium (rs11593766, rs3124740, rs11196445, and rs11196418) and associated with the risk for endometrial cancer. The AA genotype of rs11196418 [odds ratio, 0.36; 95% confidence interval (95% CI), 0.14-0.94] and the G allele of rs11593766 were associated with reduced risk (odds ratio of 0.75 and 95% CI of 0.59-0.96 for carriers of one G allele; odds ratio of 0.70 and 95% CI of 0.24-2.03 for carriers of two G alleles). The AA genotype of rs11196445 (odds ratio, 1.74; 95% CI, 0.99-3.05), the CC genotype of rs3124740 (odds ratio, 1.36; 95% CI, 1.06-1.75), and the GG genotype of rs10787498 in the caspase-7 gene (odds ratio, 1.90; 95% CI, 1.16-3.11) were associated with increased risk compared with homozygotes of the major alleles. The gene-disease association seemed to be more pronounced among premenopausal women, although tests for multiplicative interaction between genes and menopausal status failed to reach statistical significance. The GG genotype of rs2705901 in the caspase-3 gene was significantly associated with increased cancer risk compared with the CC genotype (odds ratio, 2.25; 95% CI, 1.03-4.95). No association was observed between polymorphisms of the caspase-8 gene and risk for endometrial cancer. These findings suggest that genetic variants in caspase-3 and caspase-7 may play a role in endometrial cancer susceptibility.

MeSH Terms
Asians/genetics Case-Control Studies Caspase 3/genetics Caspase 7/genetics Caspase 8/genetics China/epidemiology Endometrial Neoplasms/epidemiology,genetics Female Genetic Predisposition to Disease Genetic Variation Haplotypes/genetics Humans Middle Aged Polymorphism, Single Nucleotide Reproductive History Risk Assessment Risk Factors
Chemicals
Caspase 3 Caspase 7 Caspase 8
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Xu Hong-Li
Department of Epidemiology, Shanghai Cancer Institute, Cancer Institute of Shanghai Jiao Tong University, School of Public Health, Fudan University, Shanghai, PR China.
Xu Wang-Hong
Cai Qiuyin
Feng Min
Long Jirong
Zheng Wei
Xiang Yong-Bing
Shu Xiao-Ou
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Article Info
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Abbr.
Cancer Epidemiol Biomarkers Prev
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-09-0152
Published
2009-07-00
Epub
2009-00-16
Pages
2114-22
Language
English
Region
United States
NLM ID
9200608
PMCID
PMC2764360
Subset
IM
Grants
NIDDK NIH HHS · P60 DK020593 · United States
NEI NIH HHS · P30 EY08126 · United States
NCI NIH HHS · P30 CA68485 · United States
NIDDK NIH HHS · P30 DK058404 · United States
NCI NIH HHS · R01 CA092585 · United States
NCI NIH HHS · R01 CA092585-05 · United States
NCI NIH HHS · P30 CA068485 · United States
NIDDK NIH HHS · P60 DK20593 · United States
NIDDK NIH HHS · P30 DK58404 · United States
NEI NIH HHS · P30 EY008126 · United States
NCI NIH HHS · R01 CA92585 · United States
External Links
PubMed source DOI: 10.1158/1055-9965.EPI-09-0152 PMC Full Text View journal details
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