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PMID: 23465542 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Cohesin at active genes: a unifying theme for cohesin and gene expression from model organisms to humans.

Current opinion in cell biology ·Vol. 25 ·No. 3 ·2013-06-00 ·Pages 327-33

Dorsett D, Merkenschlager M

Abstract

Cohesin is an evolutionarily ancient multisubunit protein complex with a deeply conserved function: it provides cohesion between sister chromatids from the time of DNA replication in S-phase until mitosis. This cohesion facilitates repair of damage that occurs during DNA replication, and, crucially, enforces faithful segregation of chromosomes upon cell division. Cohesin also influences gene expression, and relative to sister chromatid cohesion, gene expression is exquisitely sensitive to moderate changes in cohesin activity. Early studies revealed differences in cohesin's roles in gene expression between various organisms. In all organisms examined, however, cohesin marks a subset of active genes. This review focuses on the roles of cohesin at active genes, and to what extent these roles are conserved between organisms.

MeSH Terms
Animals Cell Cycle Proteins/chemistry,genetics,metabolism Chromatids Chromosomal Proteins, Non-Histone/chemistry,genetics,metabolism DNA Repair DNA Replication Gene Expression Regulation Humans Mitosis Transcription Factors/metabolism
Chemicals
Cell Cycle Proteins Chromosomal Proteins, Non-Histone Transcription Factors cohesins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dorsett Dale
Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA. dorsettd@slu.edu
Merkenschlager Matthias
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2013.02.003
Email
dorsettd@slu.edu
Published
2013-06-00
Epub
2013-00-01
Pages
327-33
Language
English
Region
England
NLM ID
8913428
PMCID
PMC3691354
Subset
IM
Grants
NIGMS NIH HHS · R01 GM055683 · United States
NICHD NIH HHS · HD052860 · United States
Medical Research Council · MC_U120027516 · United Kingdom
NIGMS NIH HHS · GM055683 · United States
Wellcome Trust · United Kingdom
NICHD NIH HHS · P01 HD052860 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2013.02.003 PMC Full Text View journal details
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