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PMID: 23267412 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Sizing up long non-coding RNAs: do lncRNAs have secondary and tertiary structure?

Bioarchitecture ·Vol. 2 ·No. 6 ·2012-00-00 ·Pages 189-99

Novikova IV, Hennelly SP, Sanbonmatsu KY

Abstract

Long noncoding RNAs (lncRNAs) play a key role in many important areas of epigenetics, stem cell biology, cancer, signaling and brain function. This emerging class of RNAs constitutes a large fraction of the transcriptome, with thousands of new lncRNAs reported each year. The molecular mechanisms of these RNAs are not well understood. Currently, very little structural data exist. We review the available lncRNA sequence and secondary structure data. Since almost no tertiary information is available for lncRNAs, we review crystallographic structures for other RNA systems and discuss the possibilities for lncRNAs in the context of existing constraints.

Keywords
HOTAIR MALAT RNA RNA structure cancer epigenetics hormone receptor lincRNA lncRNA long noncoding RNA non-coding secondary structure structural biology
MeSH Terms
Animals Base Sequence Humans Models, Molecular Molecular Sequence Data Nucleic Acid Conformation RNA, Long Noncoding/chemistry,genetics,metabolism
Chemicals
RNA, Long Noncoding
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Novikova Irina V
Los Alamos National Laboratory, NM, USA.
Hennelly Scott P
Sanbonmatsu Karissa Y
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Article Info
Journal
Bioarchitecture
Abbr.
Bioarchitecture
ISSN
1949-100X
DOI
10.4161/bioa.22592
Published
2012-00-00
Pages
189-99
Language
English
Region
United States
NLM ID
101518332
PMCID
PMC3527312
Subset
IM
External Links
PubMed source DOI: 10.4161/bioa.22592 PMC Full Text
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