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PMID: 23267358 Published · epublish English Journal Article

Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection.

Frontiers in immunology ·Vol. 3 ·2012-00-00 ·Pages 371

Russ BE, Denton AE, Hatton L, Croom H, Olson MR, Turner SJ

Abstract

A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.

Keywords
cytotoxic T cells epigenetics histone modifications memory T cells transcription factors
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Russ Brendan E
Department of Microbiology and Immunology, University of Melbourne Parkville, VIC, Australia.
Denton Alice E
Hatton Lauren
Croom Hayley
Olson Matthew R
Turner Stephen J
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Article Info
Journal
Frontiers in immunology
Abbr.
Front Immunol
ISSN
1664-3224
DOI
10.3389/fimmu.2012.00371
Published
2012-00-00
Epub
2012-00-19
Pages
371
Language
English
Region
Switzerland
NLM ID
101560960
PMCID
PMC3525900
External Links
PubMed source DOI: 10.3389/fimmu.2012.00371 PMC Full Text View journal details
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