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PMID: 15163797 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 101 ·No. 23 ·2004-06-08 ·Pages 8670-5

Belz GT, Smith CM, Kleinert L, Reading P, Brooks A, Shortman K, Carbone FR, Heath WR

Abstract

During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8alpha(-)CD11b(-) DC subset and distinct CD8alpha(+) lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.

MeSH Terms

Animals Antigen Presentation Cell Movement Dendritic Cells/classification,immunology,pathology Herpes Simplex/immunology,pathology Herpesvirus 1, Human Histocompatibility Antigens Class I/metabolism In Vitro Techniques Lung Diseases/immunology,pathology Mice Mice, Inbred C57BL Mice, Transgenic Orthomyxoviridae Infections/immunology,pathology T-Lymphocytes, Cytotoxic/immunology

Chemicals

Histocompatibility Antigens Class I

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Belz Gabrielle T

Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia. belz@wehi.edu.au

Smith Christopher M

Kleinert Lauren

Reading Patrick

Brooks Andrew

Shortman Ken

Carbone Francis R

Heath William R

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.0402644101

belz@wehi.edu.au

Published

2004-06-08

Epub

2004-00-26

Pages

8670-5

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC423253

Subset

External Links

PubMed source DOI: 10.1073/pnas.0402644101 PMC Full Text View journal details

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Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus.

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