Home LiteratureArticle Details
PMID: 22797518 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Gut microbiota composition correlates with diet and health in the elderly.

Nature ·Vol. 488 ·No. 7410 ·2012-08-09 ·Pages 178-84

Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, Cusack S, Harris HM, Coakley M, Lakshminarayanan B, O'Sullivan O, Fitzgerald GF, Deane J, O'Connor M, Harnedy N, O'Connor K, O'Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, Ross RP, O'Toole PW

Abstract

Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.

MeSH Terms
Aged Aged, 80 and over Aging/physiology Cohort Studies Diet/statistics & numerical data Diet Surveys Feces/microbiology Fruit Geriatric Assessment Health Health Status Health Surveys Homes for the Aged Hospitals, Community Humans Intestines/microbiology Meat Metagenome/physiology Rehabilitation Centers Surveys and Questionnaires Vegetables
Authors & Affiliations
26 authors, click to expand affiliations / ORCID
Claesson Marcus J
Department of Microbiology, University College Cork, Ireland.
Jeffery Ian B
Conde Susana
Power Susan E
O'Connor Eibhlís M
Cusack Siobhán
Harris Hugh M B
Coakley Mairead
Lakshminarayanan Bhuvaneswari
O'Sullivan Orla
Fitzgerald Gerald F
Deane Jennifer
O'Connor Michael
Harnedy Norma
O'Connor Kieran
O'Mahony Denis
van Sinderen Douwe
Wallace Martina
Brennan Lorraine
Stanton Catherine
Marchesi Julian R
Fitzgerald Anthony P
Shanahan Fergus
Hill Colin
Ross R Paul
O'Toole Paul W
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature11319
Published
2012-08-09
Pages
178-84
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/nature11319 View journal details
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