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PMID: 22796207 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Endosomal crosstalk: meeting points for signaling pathways.

Trends in cell biology ·Vol. 22 ·No. 9 ·2012-09-00 ·Pages 447-56

Pálfy M, Reményi A, Korcsmáros T

Abstract

Endocytosis participates in downregulating incoming signals, but 'signaling endosomes' may also serve as physical platforms for crosstalk between signaling pathways. Here, we briefly review the role of endosomes in signaling crosstalk and suggest that endosome-associated scaffold proteins mediate this crosstalk. In addition, using a proteome-wide in silico approach - in which we analyze endosome-binding properties and the capacity of candidates to recruit signaling proteins from more than one distinct pathway - we extend the list of putative crosstalk-mediating endosomal scaffolds. Because endosomal crosstalk may be an important systems-level regulator of pathway communication, scaffold proteins that mediate this crosstalk could be potential targets for pharmacological intervention and synthetic engineering.

MeSH Terms
Animals Endosomes/metabolism Humans Protein Binding Protein Engineering Signal Transduction
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pálfy Máté
Department of Genetics, Eötvös Loránd University, Pázmány P. s. 1/C, Budapest, H-1117, Hungary.
Reményi Attila
Korcsmáros Tamás
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
1879-3088
DOI
10.1016/j.tcb.2012.06.004
Published
2012-09-00
Epub
2012-00-14
Pages
447-56
Language
English
Region
England
NLM ID
9200566
PMCID
PMC3430897
Subset
IM
Grants
Wellcome Trust · 081665/Z/06/Z · United Kingdom
External Links
PubMed source DOI: 10.1016/j.tcb.2012.06.004 PMC Full Text View journal details
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