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PMID: 16493415 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Critical nodes in signalling pathways: insights into insulin action.

Nature reviews. Molecular cell biology ·Vol. 7 ·No. 2 ·2006-02-00 ·Pages 85-96

Taniguchi CM, Emanuelli B, Kahn CR

Abstract

Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

MeSH Terms

Animals Humans Insulin/physiology Phosphatidylinositol 3-Kinases/metabolism Proto-Oncogene Proteins c-akt/metabolism Receptor, Insulin/physiology Signal Transduction

Chemicals

Insulin Phosphatidylinositol 3-Kinases Receptor, Insulin Proto-Oncogene Proteins c-akt

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Taniguchi Cullen M

Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.

Emanuelli Brice

Kahn C Ronald

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/nrm1837

Published

2006-02-00

Pages

85-96

Language

English

Region

England

NLM ID

100962782

Subset

Grants

NIDDK NIH HHS · R01 DK031036 · United States

External Links

PubMed source DOI: 10.1038/nrm1837 View journal details

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Critical nodes in signalling pathways: insights into insulin action.

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