Get on the exosome bus with ALIX.

Nature cell biology ·Vol. 14 ·No. 7 ·2012-06-29 ·Pages 654-5

Hurley JH, Odorizzi G

Abstract

Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysosomal pathway.

MeSH Terms

Animals Calcium-Binding Proteins/metabolism Cell Cycle Proteins/metabolism Endosomal Sorting Complexes Required for Transport/metabolism Exosomes/metabolism Humans Signal Transduction Syndecans/metabolism Syntenins/metabolism

Chemicals

Calcium-Binding Proteins Cell Cycle Proteins Endosomal Sorting Complexes Required for Transport PDCD6IP protein, human Pdcd6ip protein, mouse Syndecans Syntenins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hurley James H

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. James.hurley@nih.gov

Odorizzi Greg

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15 references, click to expand

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Article Info

Journal

Nature cell biology

Abbr.

Nat Cell Biol

ISSN

1476-4679

DOI

10.1038/ncb2530

james.hurley@nih.gov

Published

2012-06-29

Epub

2012-00-29

Pages

654-5

Language

English

Region

England

NLM ID

100890575

Subset

Corrections

CommentOn

PMID: 22660413

External Links

PubMed source DOI: 10.1038/ncb2530 View journal details

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