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PMID: 22713869 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers.

Genes & development ·Vol. 26 ·No. 12 ·2012-06-15 ·Pages 1287-99

D'Souza-Schorey C, Clancy JW

Abstract

Recent advances in the study of tumor-derived microvesicles reveal new insights into the cellular basis of disease progression and the potential to translate this knowledge into innovative approaches for cancer diagnostics and personalized therapy. Tumor-derived microvesicles are heterogeneous membrane-bound sacs that are shed from the surfaces of tumor cells into the extracellular environment. They have been thought to deposit paracrine information and create paths of least resistance, as well as be taken up by cells in the tumor microenvironment to modulate the molecular makeup and behavior of recipient cells. The complexity of their bioactive cargo-which includes proteins, RNA, microRNA, and DNA-suggests multipronged mechanisms by which microvesicles can condition the extracellular milieu to facilitate disease progression. The formation of these shed vesicles likely involves both a redistribution of surface lipids and the vertical trafficking of cargo to sites of microvesicle biogenesis at the cell surface. Current research also suggests that molecular profiling of these structures could unleash their potential as circulating biomarkers as well as platforms for personalized medicine. Thus, new and improved strategies for microvesicle identification, isolation, and capture will have marked implications in point-of-care diagnostics for cancer patients.

MeSH Terms
Biomarkers, Tumor/metabolism Cell-Derived Microparticles/metabolism Extracellular Space/metabolism Humans Neoplasms/metabolism,pathology Precision Medicine Tumor Microenvironment
Chemicals
Biomarkers, Tumor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
D'Souza-Schorey Crislyn
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA. cdsouzas@nd.edu
Clancy James W
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
1549-5477
Published
2012-06-15
Pages
1287-99
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC3387656
Subset
IM
Grants
NCI NIH HHS · R01 CA115316 · United States
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