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PMID: 22645520 Published · epublish English Journal Article

Role of the wnt pathway in thyroid cancer.

Frontiers in endocrinology ·Vol. 3 ·2012-00-00 ·Pages 31

Sastre-Perona A, Santisteban P

Abstract

Aberrant activation of Wnt signaling is involved in the development of several epithelial tumors. Wnt signaling includes two major types of pathways: (i) the canonical or Wnt/β-catenin pathway; and (ii) the non-canonical pathways, which do not involve β-catenin stabilization. Among these pathways, the Wnt/β-catenin pathway has received most attention during the past years for its critical role in cancer. A number of publications emphasize the role of the Wnt/β-catenin pathway in thyroid cancer. This pathway plays a crucial role in development and epithelial renewal, and components such as β-catenin and Axin are often mutated in thyroid cancer. Although it is accepted that altered Wnt signaling is a late event in thyroid cell transformation that affects anaplastic thyroid tumors, recent data suggest that it is also altered in papillary thyroid carcinoma (PTC) with RET/PTC mutations. Therefore, the purpose of this review is to summarize the main relevant data of Wnt signaling in thyroid cancer, with special emphasis on the Wnt/β-catenin pathway.

Keywords
Wnt pathway differentiation proliferation signaling network thyroid cancer
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sastre-Perona Ana
Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas, y Universidad Autónoma de Madrid Madrid, Spain.
Santisteban Pilar
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Article Info
Journal
Frontiers in endocrinology
Abbr.
Front Endocrinol (Lausanne)
ISSN
1664-2392
DOI
10.3389/fendo.2012.00031
Published
2012-00-00
Epub
2012-00-29
Pages
31
Language
English
Region
Switzerland
NLM ID
101555782
PMCID
PMC3355838
External Links
PubMed source DOI: 10.3389/fendo.2012.00031 PMC Full Text View journal details
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