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PMID: 22546862 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Uncovering the role of genomic "dark matter" in human disease.

The Journal of clinical investigation ·Vol. 122 ·No. 5 ·2012-05-00 ·Pages 1589-95

Martin L, Chang HY

Abstract

The human genome encodes thousands of long noncoding RNAs (lncRNAs). Although most remain functionally uncharacterized biological "dark matter," lncRNAs have garnered considerable attention for their diverse roles in human biology, including developmental programs and tumor suppressor gene networks. As the number of lncRNAs associated with human disease grows, ongoing research efforts are focusing on their regulatory mechanisms. New technologies that enable enumeration of lncRNA interaction partners and determination of lncRNA structure are well positioned to drive deeper understanding of their functions and involvement in pathogenesis. In turn, lncRNAs may become targets for therapeutic intervention or new tools for biotechnology.

MeSH Terms
Animals Cell Cycle Gene Expression Regulation Genome, Human Humans Neoplasms/genetics,metabolism RNA, Untranslated/genetics,metabolism,physiology Transcription, Genetic
Chemicals
RNA, Untranslated
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Martin Lance
Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
Chang Howard Y
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
1558-8238
DOI
10.1172/JCI60020
Published
2012-05-00
Epub
2012-00-01
Pages
1589-95
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC3336981
Subset
IM
Grants
NCI NIH HHS · R01 CA118750 · United States
NHGRI NIH HHS · R01 HG004361 · United States
External Links
PubMed source DOI: 10.1172/JCI60020 PMC Full Text View journal details
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