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PMID: 2247083 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3 and PC12 cells.

Molecular and cellular biology ·Vol. 10 ·No. 12 ·1990-12-00 ·Pages 6769-74

Charles CH, Simske JS, O'Brien TP, Lau LF

Abstract

pip92 is a cellular immediate-early gene inducible by serum growth factors in fibroblasts. It is also induced in the rat pheochromocytoma cell line PC12 by agents that cause proliferation, neuronal differentiation, and membrane depolarization. We show that the pip92-encoded polypeptide is a proline-rich protein of 221 amino acids, has an extremely short half-life, and is localized in the cytoplasm. We hypothesize that Pip92 plays a role in mediating the cellular responses to a variety of extracellular signals.

MeSH Terms
Adrenal Gland Neoplasms Amino Acid Sequence Animals Base Sequence Cell Line DNA/genetics Fibroblast Growth Factors/pharmacology Gene Library Growth Substances/pharmacology Half-Life Immediate-Early Proteins Mice Molecular Sequence Data Peptide Biosynthesis Peptides/genetics,metabolism Pheochromocytoma Platelet-Derived Growth Factor/pharmacology Proline-Rich Protein Domains Protein Biosynthesis Proteins/genetics,metabolism RNA, Messenger/genetics Rats Tetradecanoylphorbol Acetate/pharmacology
Chemicals
Growth Substances Immediate-Early Proteins Peptides Platelet-Derived Growth Factor Proteins RNA, Messenger pip92 protein, rat Ier2 protein, mouse Fibroblast Growth Factors DNA Tetradecanoylphorbol Acetate
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Charles C H
Department of Genetics, University of Illinois College of Medicine, Chicago 60612.
Simske J S
O'Brien T P
Lau L F
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.10.12.6769-6774.1990
Published
1990-12-00
Pages
6769-74
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC362956
Subset
IM
Grants
NCI NIH HHS · R01 CA46565 · United States
NCI NIH HHS · R01 CA52220 · United States
Databases
GENBANK
M33756, M59821
External Links
PubMed source DOI: 10.1128/mcb.10.12.6769-6774.1990 PMC Full Text View journal details
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