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PMID: 22403589 Published · ppublish English Journal Article

Cellular networks controlling Th2 polarization in allergy and immunity.

F1000 biology reports ·Vol. 4 ·2012-00-00 ·Pages 6

Kool M, Hammad H, Lambrecht BN

Abstract

In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of allergy. A picture is emerging in which mucosal epithelial cells instruct dendritic cells to promote Th2 responses in the absence of IL-12 (interleukin 12) production and provide instruction through thymic stromal lymphopoieitin (TSLP) or granulocyte-macrophage colony stimulating factor (GM-CSF). At the same time, allergens, helminths and chemical adjuvants elicit the response of innate immune cells like basophils, which provide more polarizing cytokines and IL-4 and reinforce Th2 immunity. This unique communication between cells will only be fully appreciated if we study Th2 immunity in vivo and in a tissue-specific context, and can only be fully understood if we compare several models of Th2 immune response induction.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kool Mirjam
Hammad Hamida
Lambrecht Bart N
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Article Info
Journal
F1000 biology reports
Abbr.
F1000 Biol Rep
ISSN
1757-594X
DOI
10.3410/B4-6
Published
2012-00-00
Epub
2012-00-01
Pages
6
Language
English
Region
England
NLM ID
101506835
PMCID
PMC3292286
External Links
PubMed source DOI: 10.3410/B4-6 PMC Full Text
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