How to activate a gene: decap its associated noncoding RNA.

Molecular cell ·Vol. 45 ·No. 3 ·2012-02-10 ·Pages 271-3

Ramaiah M, Shum EY, Wilkinson MF

Abstract

Capped and polyadenylated long noncoding RNAs (lncRNAs) are shown to be degraded by a DCP2-mediated turnover mechanism by Geisler et al. (2012); this provides a new level of regulatory control for inducible genes by lncRNAs.

MeSH Terms

Exoribonucleases/genetics Gene Expression Regulation, Fungal RNA Caps/metabolism RNA Processing, Post-Transcriptional RNA, Untranslated/metabolism Saccharomyces cerevisiae/genetics Saccharomyces cerevisiae Proteins/genetics

Chemicals

RNA Caps RNA, Untranslated Saccharomyces cerevisiae Proteins RAT1 protein, S cerevisiae Exoribonucleases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ramaiah Madhuvanthi

Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0695, USA.

Shum Eleen Y

Wilkinson Miles F

References (10)

10 references, click to expand

Molecular mechanisms of long noncoding RNAs.
Mol Cell. 2011 Sep 16;43(6):904-14 PMID: 21925379
Messenger RNA turnover in eukaryotes: pathways and enzymes.
Crit Rev Biochem Mol Biol. 2004 Jul-Aug;39(4):197-216 PMID: 15596551
Accumulation of miR-155 and BIC RNA in human B cell lymphomas.
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3627-32 PMID: 15738415
Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae.
Mol Cell Biol. 2007 Jan;27(1):92-101 PMID: 17074811
A ncRNA modulates histone modification and mRNA induction in the yeast GAL gene cluster.
Mol Cell. 2008 Dec 5;32(5):685-95 PMID: 19061643
The highways and byways of mRNA decay.
Nat Rev Mol Cell Biol. 2007 Feb;8(2):113-26 PMID: 17245413
Dcp2 phosphorylation by Ste20 modulates stress granule assembly and mRNA decay in Saccharomyces cerevisiae.
J Cell Biol. 2010 May 31;189(5):813-27 PMID: 20513766
Decapping of long noncoding RNAs regulates inducible genes.
Mol Cell. 2012 Feb 10;45(3):279-91 PMID: 22226051
H3 lysine 4 di- and tri-methylation deposited by cryptic transcription attenuates promoter activation.
EMBO J. 2009 Jun 17;28(12):1697-707 PMID: 19407817
XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast.
Nature. 2011 Jun 22;475(7354):114-7 PMID: 21697827

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-4164

DOI

10.1016/j.molcel.2012.01.014

Published

2012-02-10

Pages

271-3

Language

English

Region

United States

NLM ID

9802571

PMCID

PMC4281020

Subset

Grants

NIGMS NIH HHS · R01 GM058595 · United States

Corrections

CommentOn

PMID: 22226051

External Links

PubMed source DOI: 10.1016/j.molcel.2012.01.014 PMC Full Text View journal details

Analysis Services

How to activate a gene: decap its associated noncoding RNA.

Contact

WeChat Official Account