Decreased binding of polymyxin by polymyxin-resistant mutants of Salmonella typhimurium.

Journal of bacteriology ·Vol. 139 ·No. 2 ·1979-08-00 ·Pages 664-7

Vaara M, Vaara T, Sarvas M

Abstract

Polymyxin-resistant pmrA strains were shown to absorb only about 25% of the amount of polymyxin absorbed by the corresponding polymyxin-sensitive parent strains. The lipopolysaccharide from the pmrA strains bound less polymyxin than the lipopolysaccharide from the parent strains.

MeSH Terms

Drug Resistance, Microbial Lipopolysaccharides/metabolism Membrane Lipids/analysis Mutation Polymyxin B/metabolism,pharmacology Polymyxins/metabolism Receptors, Drug/metabolism Salmonella typhimurium/drug effects,metabolism

Chemicals

Lipopolysaccharides Membrane Lipids Polymyxins Receptors, Drug Polymyxin B

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Vaara M

Vaara T

Sarvas M

References (17)

17 references, click to expand

STUDIES ON THE GRAM-NEGATIVE CELL WALL. I. EVIDENCE FOR THE ROLE OF 2-KETO- 3-DEOXYOCTONATE IN THE LIPOPOLYSACCHARIDE OF SALMONELLA TYPHIMURIUM.
Proc Natl Acad Sci U S A. 1963 Sep;50:499-506 PMID: 14067096
Action of polymyxin B on bacterial membranes: morphological changes in the cytoplasm and in the outer membrane of Salmonella typhimurium and Escherichia coli B.
Antimicrob Agents Chemother. 1975 Jul;8(1):95-104 PMID: 169730
A new method for the extraction of R lipopolysaccharides.
Eur J Biochem. 1969 Jun;9(2):245-9 PMID: 5804498
Action of polymyxin B on bacterial membranes. Binding capacities for polymyxin B of inner and outer membranes isolated from Salmonella typhimurium G30.
Arch Microbiol. 1976 Aug;109(1-2):51-8 PMID: 183617
Effect of polymyxin on the ultrastructure of the outer membrane of wild-type and polymyxin-resistant strain of Salmonella.
J Bacteriol. 1976 Sep;127(3):1400-7 PMID: 182675
Outer membrane of Salmonella typhimurium: chemical analysis and freeze-fracture studies with lipopolysaccharide mutants.
J Bacteriol. 1975 Nov;124(2):942-58 PMID: 1102538
Ultrastructural study of polymyxin-resistant isolates of Pseudomonas aeruginosa.
J Bacteriol. 1976 Jan;125(1):267-81 PMID: 173706
Use of polymyxin B, levallorphan, and tetracaine to isolate novel envelope mutants of Escherichia coli.
J Bacteriol. 1976 Aug;127(2):961-72 PMID: 182670
Polymyxin and related peptide antibiotics.
Annu Rev Biochem. 1977;46:723-63 PMID: 197881
Quantitative correlation of uptake with antibiotic activity of polymyxin B in Salmonella typhimurium.
FEBS Lett. 1971 Aug 15;16(3):195-197 PMID: 11945938
Lipid and lipopolysaccharide composition of Escherichia coli surface-altered mutants selected for resistance to levallorphan, tetracaine, and polymyxin.
J Bacteriol. 1979 Feb;137(2):1043-7 PMID: 217864
Action of polymyxin B on bacterial membranes. 1. Binding to the O-antigenic lipopolysaccharide of Salmonella typhimurium.
Z Naturforsch C. 1973 Jul-Aug;28(7):422-30 PMID: 4358580
Preparation of biologically active mono-N-acetyl (14C)-derivatives of the membrane-specific polypeptide antibiotic polymyxin B.
Z Naturforsch B. 1970 Jan;25(1):117 PMID: 4391920
Effect of polymyxin on the outer membrane of Salmonella typhimurium: freeze-fracture studies.
J Bacteriol. 1976 Nov;128(2):665-7 PMID: 185199
Differential release of periplasmic versus cytoplasmic enzymes from Escherichia coli B by polymixin B.
Arch Mikrobiol. 1971;78(2):166-79 PMID: 4327868
Low magnesium and phospholipid content of cell wals of Pseudomonas aeruginosa resistant to polymyxin.
Nature. 1970 Sep 26;227(5265):1360-1 PMID: 4318375
Basis for the selectivity of action of the polymyxin antibiotics on cell membranes.
Ann N Y Acad Sci. 1974 May 10;235(0):480-92 PMID: 4368447

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.139.2.664-667.1979

Published

1979-08-00

Pages

664-7

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC216918

Subset

External Links

PubMed source DOI: 10.1128/jb.139.2.664-667.1979 PMC Full Text View journal details

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Decreased binding of polymyxin by polymyxin-resistant mutants of Salmonella typhimurium.

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