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PMID: 22258243 Published · ppublish English Journal Article Review

Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion.

Journal of virology ·Vol. 86 ·No. 6 ·2012-03-00 ·Pages 2900-10

Jensen S, Thomsen AR

Abstract

Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.

MeSH Terms
Animals Humans Immunity, Innate RNA Virus Infections/genetics,immunology,virology RNA Viruses/genetics,immunology Receptors, Immunologic/genetics,immunology
Chemicals
Receptors, Immunologic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jensen Søren
Institute of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Thomsen Allan Randrup
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
1098-5514
DOI
10.1128/JVI.05738-11
Published
2012-03-00
Epub
2012-00-18
Pages
2900-10
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC3302314
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.05738-11 PMC Full Text View journal details
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