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PMID: 21267015 Published · ppublish English Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Recognition of herpesviruses by the innate immune system.

Nature reviews. Immunology ·Vol. 11 ·No. 2 ·2011-00-00 ·Pages 143-54

Paludan SR, Bowie AG, Horan KA, Fitzgerald KA

Abstract

Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular compartments. This has shed light on how herpesviruses, which are large disease-causing DNA viruses that replicate in the nucleus, are initially recognized during cellular infection. Surprisingly, this involves multiple PRRs both on the cell surface and within endosomes and the cytosol. In this article we describe recent advances in our understanding of innate detection of herpesviruses, how this innate detection translates into anti-herpesvirus host defence, and how the viruses seek to evade this innate detection to establish persistent infections.

MeSH Terms
DNA, Viral/immunology Herpesviridae/immunology Herpesviridae Infections/immunology Host-Pathogen Interactions/immunology Humans Immunity, Innate RNA, Viral/immunology Receptors, Pattern Recognition/immunology Signal Transduction Toll-Like Receptors/immunology
Chemicals
DNA, Viral RNA, Viral Receptors, Pattern Recognition Toll-Like Receptors
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Paludan Søren R
Department of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK-8000 Aarhus C, Denmark. srp@microbiology.au.dk
Bowie Andrew G
Horan Kristy A
Fitzgerald Katherine A
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2937
Email
srp@microbiology.au.dk
Published
2011-00-00
Pages
143-54
Language
English
Region
England
NLM ID
101124169
PMCID
PMC3686362
Subset
IM
Grants
NIAID NIH HHS · R01 AI064349 · United States
NIAID NIH HHS · R01 AI079293 · United States
NIAID NIH HHS · R01 AI067497 · United States
NIAID NIH HHS · AI64349 · United States
NIAID NIH HHS · R56 AI067497 · United States
NIAID NIH HHS · AI067497 · United States
NIAID NIH HHS · R01 AI083713-03 · United States
NIAID NIH HHS · R01 AI083641-01 · United States
NIAID NIH HHS · AI079293 · United States
NIAID NIH HHS · R01 AI083713 · United States
NIAID NIH HHS · AI083713 · United States
NIAID NIH HHS · R01 AI083713-04 · United States
NIAID NIH HHS · R37 AI067497 · United States
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PubMed source DOI: 10.1038/nri2937 PMC Full Text View journal details
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