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PMID: 22245779 Published · epublish English Journal Article Research Support, N.I.H., Extramural

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection.

Nature medicine ·Vol. 18 ·No. 2 ·2012-01-15 ·Pages 260-6

Chen F, Liu Z, Wu W, Rozo C, Bowdridge S, Millman A, Van Rooijen N, Urban JF, Wynn TA, Gause WC

Abstract

Helminths induce potent T helper 2 (TH2)-type immune responses that can mediate worm expulsion, but the role of this response in controlling the acute tissue damage caused by migrating multicellular parasites through vital tissues remains uncertain. We used a helminth infection model in which parasitic nematode larvae migrate transiently through the lung, resulting in hemorrhage and inflammation. We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL-17 mRNA levels, enhanced the expression of insulin-like growth factor 1 (IGF-1) and IL-10 and stimulated the development of M2 macrophages, all of which contributed to the rapid resolution of tissue damage. These studies indicate an essential role for TH2-type immune responses in mediating acute wound healing during helminth infection.

MeSH Terms
Animals Female Helminthiasis, Animal/immunology Hemorrhage/immunology,parasitology Immunity, Cellular Inflammation/immunology,parasitology Insulin-Like Growth Factor I/physiology Interleukin-17/physiology Interleukin-4/physiology Lung/blood supply,immunology,parasitology Lung Diseases, Parasitic/immunology,parasitology Macrophages/immunology,physiology Mice Mice, Inbred BALB C Neutrophil Infiltration/immunology Neutrophils/physiology Nippostrongylus/immunology Strongylida Infections/immunology Th2 Cells/physiology
Chemicals
Interleukin-17 Interleukin-4 Insulin-Like Growth Factor I
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Chen Fei
Department of Medicine and Center for Immunity and Inflammation, New Jersey Medical School, University of Medicine & Dentistry of New Jersey, Newark, New Jersey, USA.
Liu Zhugong
Wu Wenhui
Rozo Cristina
Bowdridge Scott
Millman Ariel
Van Rooijen Nico
Urban Joseph F
Wynn Thomas A
Gause William C
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Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1546-170X
DOI
10.1038/nm.2628
Published
2012-01-15
Epub
2012-00-15
Pages
260-6
Language
English
Region
United States
NLM ID
9502015
PMCID
PMC3274634
Subset
IM
Grants
NIAID NIH HHS · R01 AI066188-04 · United States
NIAID NIH HHS · R01 AI066188-02 · United States
NIAID NIH HHS · R01 AI066188-01A1 · United States
NIAID NIH HHS · R01 AI066188-05 · United States
NIAID NIH HHS · R01 AI066188-03 · United States
NIAID NIH HHS · R01 AI066188 · United States
NIAID NIH HHS · AI031678 · United States
NIAID NIH HHS · R01 AI031678 · United States
External Links
PubMed source DOI: 10.1038/nm.2628 PMC Full Text View journal details
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