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PMID: 20357259 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural

B cells have distinct roles in host protection against different nematode parasites.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 184 ·No. 9 ·2010-05-01 ·Pages 5213-23

Liu Q, Kreider T, Bowdridge S, Liu Z, Song Y, Gaydo AG, Urban JF, Gause WC

Abstract

B cells can mediate protective responses against nematode parasites by supporting Th2 cell development and/or by producing Abs. To examine this, B cell-deficient mice were inoculated with Nippostrongylus brasiliensis or Heligmosomoides polygyrus. B cell-deficient and wild type mice showed similar elevations in Th2 cytokines and worm expulsion after N. brasiliensis inoculation. Worm expulsion was inhibited in H. polygyrus-inoculated B cell-deficient mice, although Th2 cytokine elevations in mucosal tissues were unaffected. Impaired larval migration and development was compromised as early as day 4 after H. polygyrus challenge, and administration of immune serum restored protective immunity in B cell-deficient mice, indicating a primary role for Ab. Immune serum even mediated protective effects when administered to naive mice prior to inoculation. This study suggests variability in the importance of B cells in mediating protection against intestinal nematode parasites, and it indicates an important role for Ab in resistance to tissue-dwelling parasites.

MeSH Terms
Animals B-Lymphocyte Subsets/immunology,parasitology,transplantation Female Host-Parasite Interactions/immunology Immunologic Memory Mice Mice, Inbred BALB C Mice, Mutant Strains Nematospiroides dubius/growth & development,immunology Nippostrongylus/growth & development,immunology Strongylida Infections/immunology,pathology,prevention & control Th2 Cells/immunology,parasitology,pathology
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Liu Qian
Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA.
Kreider Timothy
Bowdridge Scott
Liu Zhugong
Song Youngmia
Gaydo Andrew G
Urban Joseph F
Gause William C
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Article Info
Journal
Journal of immunology (Baltimore, Md. : 1950)
Abbr.
J Immunol
ISSN
1550-6606
DOI
10.4049/jimmunol.0902879
Published
2010-05-01
Epub
2010-00-31
Pages
5213-23
Language
English
Region
United States
NLM ID
2985117R
PMCID
PMC3729113
Subset
IM
Grants
NIAID NIH HHS · R01 AI031678 · United States
NIAID NIH HHS · AI031678 · United States
External Links
PubMed source DOI: 10.4049/jimmunol.0902879 PMC Full Text View journal details
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