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PMID: 22237392 Published · epublish English Research Support, Non-U.S. Gov't Review

Cancer stem cells: an evolving concept.

Nature reviews. Cancer ·Vol. 12 ·No. 2 ·2012-00-12 ·Pages 133-43

Nguyen LV, Vanner R, Dirks P, Eaves CJ

Abstract

The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. This idea is not new, but has recently gained prominence because of advances in defining normal tissue hierarchies, a greater appreciation of the multistep nature of oncogenesis and improved methods to propagate primary human cancers in immunodeficient mice. As a result we have obtained new insights into why the CSC concept is not universally applicable, as well as a new basis for understanding the complex evolution, phenotypic heterogeneity and therapeutic challenges of many human cancers.

MeSH Terms
Animals Genomic Instability Humans Mice Neoplastic Stem Cells/cytology Stochastic Processes Transplantation, Heterologous
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Nguyen Long V
Terry Fox Laboratory, British Columbia Cancer Agency and the University of British Columbia, 675 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada.
Vanner Robert
Dirks Peter
Eaves Connie J
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3184
Published
2012-00-12
Epub
2012-00-12
Pages
133-43
Language
English
Region
England
NLM ID
101124168
Subset
IM
Grants
CIHR · Canada
External Links
PubMed source DOI: 10.1038/nrc3184 View journal details
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