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PMID: 21727135 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Stem cells for skeletal muscle repair.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 366 ·No. 1575 ·2011-08-12 ·Pages 2297-306

Shadrach JL, Wagers AJ

Abstract

Skeletal muscle is a highly specialized tissue composed of non-dividing, multi-nucleated muscle fibres that contract to generate force in a controlled and directed manner. Skeletal muscle is formed during embryogenesis from a subset of muscle precursor cells, which generate both differentiated muscle fibres and specialized muscle-forming stem cells known as satellite cells. Satellite cells remain associated with muscle fibres after birth and are responsible for muscle growth and repair throughout life. Failure in satellite cell function can lead to delayed, impaired or failed recovery after muscle injury, and such failures become increasingly prominent in cases of progressive muscle disease and in old age. Recent progress in the isolation of muscle satellite cells and elucidation of the cellular and molecular mediators controlling their activity indicate that these cells represent promising therapeutic targets. Such satellite cell-based therapies may involve either direct cell replacement or development of drugs that enhance endogenous muscle repair mechanisms. Here, we discuss recent breakthroughs in understanding both the cell intrinsic and extrinsic regulators that determine the formation and function of muscle satellite cells, as well as promising paths forward to realizing their full therapeutic potential.

MeSH Terms
Drug Discovery Humans Muscle, Skeletal/physiology Satellite Cells, Skeletal Muscle/physiology Stem Cell Transplantation Stem Cells/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shadrach Jennifer L
Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard University and Joslin Diabetes Center, Bauer Center, 7 Divinity Avenue, Cambridge, MA 02138, USA.
Wagers Amy J
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Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
1471-2970
DOI
10.1098/rstb.2011.0027
Published
2011-08-12
Pages
2297-306
Language
English
Region
England
NLM ID
7503623
PMCID
PMC3130421
Subset
IM
Grants
NIA NIH HHS · R01 AG033053 · United States
NIA NIH HHS · AG033053 · United States
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1098/rstb.2011.0027 PMC Full Text View journal details
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